2-Bromo-5-fluoro-3-nitropyridine
- CAS No.652160-72-0
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High purity 2-Bromo-5-fluoro-3-nitropyridine is a key fluorinated building block for pharmaceutical synthesis. We supply bulk quantities with strict quality control and timely delivery.
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Product Overview
2-Bromo-5-fluoro-3-nitropyridine is a highly specialized fluorinated heterocyclic compound designed for advanced organic synthesis and pharmaceutical development. As a critical building block, this molecule features a pyridine core substituted with bromine, fluorine, and nitro groups, offering versatile reactivity for complex molecular constructions. Our manufacturing process ensures exceptional purity levels, making it an ideal choice for researchers and industrial chemists focused on developing novel therapeutic agents.
The strategic placement of halogen substituents on the pyridine ring facilitates various cross-coupling reactions, including Suzuki, Heck, and Buchwald-Hartwig aminations. This chemical profile is essential for medicinal chemists aiming to introduce specific functional groups into lead compounds during drug discovery pipelines. We maintain rigorous production standards to guarantee consistency across all batches.
Key Specifications
| Parameter | Value |
|---|---|
| Chemical Name | 2-Bromo-5-fluoro-3-nitropyridine |
| CAS Number | 652160-72-0 |
| Molecular Formula | C5H2BrFN2O2 |
| Molecular Weight | 220.98 g/mol |
| Appearance | Light yellow powder |
| Purity | ≥98.0% |
| Density | 1.9±0.1 g/cm3 |
| Boiling Point | 227.3±35.0 °C at 760 mmHg |
| Flash Point | 91.2±25.9 °C |
Industrial Applications
This fluorinated pyridine derivative serves as a vital intermediate in the synthesis of various pharmaceutical active ingredients. Its unique electronic properties allow for selective nucleophilic aromatic substitution, enabling the construction of complex heterocyclic systems found in modern medicines. Beyond pharmaceuticals, it may also find utility in agrochemical research and material science where fluorinated motifs are required for performance enhancement.
- Pharmaceutical Intermediate: Used in the synthesis of kinase inhibitors and receptor modulators.
- Organic Synthesis: Facilitates cross-coupling reactions for building complex molecular architectures.
- Research and Development: Essential for medicinal chemistry programs focusing on fluorinated drug candidates.
- Quality Control: Each batch is tested using HPLC and NMR to ensure structural integrity and purity.
Storage and Handling
To maintain stability and safety, 2-Bromo-5-fluoro-3-nitropyridine should be stored in a tightly closed container within a cool, dry, and well-ventilated area. Avoid exposure to direct sunlight and moisture. Proper personal protective equipment, including gloves and safety goggles, is recommended during handling. We provide comprehensive safety data sheets and certificates of analysis with every shipment to ensure compliance with global regulatory standards.
