2-Bromo-5-fluoro-6-methylpyridine
- CAS No.374633-38-2
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High-purity 2-Bromo-5-fluoro-6-methylpyridine (CAS 374633-38-2) designed for advanced pharmaceutical intermediate synthesis and organic chemistry applications.
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Product Overview
2-Bromo-5-fluoro-6-methylpyridine is a highly specialized halogenated pyridine derivative engineered for use in complex organic synthesis and medicinal chemistry campaigns. As a critical building block, this compound features a unique substitution pattern with bromine, fluorine, and methyl groups on the pyridine ring, offering versatile reactivity for cross-coupling reactions and nucleophilic substitutions. Our manufacturing process ensures consistent quality suitable for scaling up pharmaceutical intermediate production.
The presence of the fluorine atom enhances metabolic stability in downstream drug candidates, while the bromine moiety serves as an excellent handle for palladium-catalyzed coupling reactions. This combination makes the substance an invaluable asset for research and development teams focused on creating novel therapeutic agents. We adhere to strict quality management systems to deliver materials that meet the rigorous demands of modern drug discovery.
Technical Specifications
| Parameter | Specification |
|---|---|
| Chemical Name | 2-Bromo-5-fluoro-6-methylpyridine |
| CAS Number | 374633-38-2 |
| Molecular Formula | C6H5BrFN |
| Molecular Weight | 190.01 g/mol |
| Appearance | White Crystalline Powder |
| Purity | ≥98.0% |
| Melting Point | 63-65 °C |
| Boiling Point | 183.4 °C at 760 mmHg |
| Density | 1.6 ±0.1 g/cm3 |
Industrial Applications
This fluorinated pyridine intermediate is primarily utilized in the synthesis of active pharmaceutical ingredients (APIs). It serves as a key precursor in the construction of heterocyclic scaffolds found in various therapeutic classes. Chemists leverage its reactivity profile to introduce specific functional groups during multi-step synthesis routes. Common applications include Suzuki-Miyaura coupling, Buchwald-Hartwig amination, and other transition metal-catalyzed transformations.
Beyond pharmaceuticals, this compound may find utility in the development of agrochemicals and advanced materials where fluorinated heterocycles are required. The high purity grade we supply minimizes impurities that could interfere with sensitive catalytic processes, ensuring higher yields and cleaner reaction profiles for our clients.
Quality Assurance and Storage
Every batch of 2-Bromo-5-fluoro-6-methylpyridine undergoes comprehensive analytical testing. We employ high-performance liquid chromatography (HPLC) and nuclear magnetic resonance (NMR) spectroscopy to verify identity and purity levels. A Certificate of Analysis (COA) is provided with each shipment to guarantee compliance with specified parameters.
- Stored in a tightly closed container to prevent moisture absorption.
- Keep in a cool, dry, and well-ventilated area away from incompatible substances.
- Protect from light and heat to maintain chemical stability over time.
- Handle with appropriate personal protective equipment during laboratory operations.
Our commitment to excellence extends from synthesis to delivery. We offer flexible packaging options, including standard 25 kg drums, to accommodate both laboratory-scale research and pilot plant requirements. For specific technical inquiries or custom synthesis needs, our expert team is available to provide detailed support and documentation.
