Intermediates

2-Bromo-5-fluorobenzoic acid

  • CAS No.394-28-5
  • GradeIndustrial / Pharmaceutical
  • Availability● In Stock

High purity 2-Bromo-5-fluorobenzoic acid (CAS 394-28-5) designed for advanced organic synthesis. Reliable supply for pharmaceutical and agrochemical intermediate production.

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Product Technical Details

Product Overview

2-Bromo-5-fluorobenzoic acid represents a critical halogenated aromatic building block within the realm of advanced organic synthesis. This compound is characterized by the presence of both bromine and fluorine substituents on the benzoic acid backbone, offering unique reactivity profiles for chemists engaged in complex molecule construction. Our facility produces this material under strict quality control standards to ensure consistency across batches, making it a reliable choice for research and industrial applications.

The dual functionality provided by the bromo and fluoro groups allows for versatile chemical transformations. The bromine atom serves as an excellent handle for palladium-catalyzed cross-coupling reactions, while the fluorine moiety is often utilized to enhance the metabolic stability and bioavailability of final drug candidates. This specific substitution pattern makes the compound highly valuable in the development of novel pharmaceutical agents and agrochemical formulations.

Specifications and Physical Properties

We adhere to rigorous testing protocols to guarantee that every shipment meets the specified purity requirements. The following table outlines the key physical and chemical parameters associated with this product.

ParameterValue
Chemical Name2-Bromo-5-fluorobenzoic acid
CAS Number394-28-5
Molecular FormulaC7H4BrFO2
Molecular Weight219.01 g/mol
AppearanceOff-white powder
Purity≥99.0%
Melting Point154-157°C
Boiling Point291.1°C
Density1.789 g/cm3

Industrial Applications

Primarily utilized as an intermediate in the pharmaceutical industry, this compound serves as a key precursor for various therapeutic agents. Medicinal chemists frequently employ this building block in the synthesis of kinase inhibitors and other targeted therapies where fluorine substitution is critical for performance. Additionally, it finds applications in agrochemical development, where halogenated aromatic acids are used to create robust herbicides and pesticides.

Beyond life sciences, the material is applicable in material science research, particularly in the development of organic electronic components and polymers. The stability of the carbon-fluorine bond ensures that derivatives maintain integrity under various environmental conditions. Our team supports clients in scaling these applications from laboratory benchtop to full commercial production.

Quality Assurance and Handling

Quality is the cornerstone of our manufacturing process. Each batch of 2-Bromo-5-fluorobenzoic acid is accompanied by a comprehensive Certificate of Analysis (COA) detailing test results against established specifications. We utilize advanced analytical techniques such as HPLC and NMR to verify identity and purity levels. This commitment to transparency ensures that downstream processes are not compromised by impurities.

For safe handling, the product should be stored in a cool, ventilated place away from incompatible materials. Standard laboratory safety protocols, including the use of personal protective equipment, are recommended during handling. We offer flexible packing options, typically 25 kg per drum, but can accommodate custom requirements based on logistical needs. Contact our sales team for detailed information on bulk pricing and global shipping arrangements.