2-Bromo-5-fluorobenzonitrile
- CAS No.57381-39-2
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High-purity 2-Bromo-5-fluorobenzonitrile (CAS 57381-39-2), a versatile halogenated aromatic intermediate for advanced organic synthesis in pharmaceutical and agrochemical R&D.
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Product Overview
2-Bromo-5-fluorobenzonitrile is a high-value halogenated aromatic building block widely employed in modern organic synthesis. With its dual functional handles—bromine for cross-coupling reactions and fluorine for metabolic stability modulation—this compound serves as a critical intermediate in the development of complex active pharmaceutical ingredients (APIs) and specialty agrochemicals. Our product is manufactured under stringent quality control protocols to ensure consistent performance in demanding synthetic applications.
Specifications
| Molecular Formula | C₇H₃BrFN |
|---|---|
| Molecular Weight | 200.008 g/mol |
| CAS Number | 57381-39-2 |
| Appearance | White crystalline powder |
| Assay | ≥98.0% |
| Melting Point | 92–95 °C (lit.) |
| Boiling Point | 251.2 ± 25.0 °C at 760 mmHg |
| Density | 1.7 ± 0.1 g/cm³ |
| Flash Point | 105.7 ± 23.2 °C |
| Vapour Pressure | 0.0 ± 0.5 mmHg at 25 °C |
| Refractive Index | 1.578 |
Industrial Applications
As a strategic intermediate, 2-Bromo-5-fluorobenzonitrile is primarily utilized in multi-step syntheses where regioselective functionalization is required. Its bromo group readily participates in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille, or Negishi couplings), while the electron-withdrawing nitrile and fluorine substituents fine-tune electronic properties and enhance molecular stability. Key application sectors include:
- Pharmaceutical R&D for novel neurological and oncological therapeutics
- Agrochemical innovation for next-generation crop protection agents
- Materials science for liquid crystals and organic electronic components
Stored in a cool, well-ventilated area away from incompatible substances, this intermediate is typically supplied in 25 kg drums or customized packaging to meet global regulatory and logistical requirements.
