2-Bromo-5-fluorobenzyl bromide

Product Overview

2-Bromo-5-fluorobenzyl bromide is a high-value dihalogenated aromatic compound widely employed as a key building block in pharmaceutical and agrochemical research. With the molecular formula C7H5Br2F and a molecular weight of 267.92 g/mol, this reagent features dual reactive sites—benzylic bromide and aryl bromide—enabling sequential functionalization strategies in complex molecule construction. Its fluorine substituent further enhances metabolic stability and binding affinity in bioactive molecule design.

Specifications

Industrial Applications

This compound serves primarily as a specialty intermediate in multi-step organic syntheses. Key application areas include:

• Preparation of fluorinated biaryl scaffolds via palladium-catalyzed cross-coupling reactions
• Synthesis of benzyl-protected amino acid derivatives and heterocyclic systems
• Development of novel active pharmaceutical ingredients (APIs) requiring precise halogen placement
• Agrochemical innovation targeting enhanced environmental persistence and selectivity

Due to its bifunctional reactivity, 2-bromo-5-fluorobenzyl bromide enables chemists to achieve regioselective transformations under controlled conditions, making it indispensable in modern medicinal chemistry workflows.

Handling and Storage

Store in a cool, dry, and well-ventilated area away from heat sources and incompatible materials such as strong bases or nucleophiles. Maintain container tightly closed to prevent moisture absorption and degradation. Standard personal protective equipment (PPE) including gloves and eye protection should be used during handling.