2-Bromo-5-fluorotoluene
- CAS No.452-63-1
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High-purity 2-Bromo-5-fluorotoluene (CAS 452-63-1) designed for pharmaceutical and agrochemical synthesis. Reliable supply with strict quality control.
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Product Overview
2-Bromo-5-fluorotoluene is a critical fluorinated aromatic intermediate widely utilized in the synthesis of complex organic molecules. As a key building block, this compound plays an essential role in the development of advanced pharmaceutical agents and agrochemical formulations. Our manufacturing process ensures high purity and consistency, meeting the rigorous demands of modern chemical research and industrial production. The strategic placement of halogen atoms on the aromatic ring provides chemists with a versatile platform for further functionalization.
The presence of both bromine and fluorine substituents on the toluene backbone provides unique reactivity profiles, enabling diverse coupling reactions such as Suzuki, Heck, and Grignard transformations. This versatility makes it a preferred choice for medicinal chemists aiming to introduce fluorine atoms into lead compounds to enhance metabolic stability and bioavailability. Fluorine incorporation is a cornerstone strategy in modern drug design, often improving lipophilicity and binding affinity.
Technical Specifications
| Parameter | Value |
|---|---|
| CAS Number | 452-63-1 |
| Molecular Formula | C7H6BrF |
| Molecular Weight | 189.02500 |
| Appearance | Colorless transparent liquid |
| Purity | ≥98% |
| Water Content | ≤0.5% |
| Density | 1.495 g/mL at 25 °C |
| Boiling Point | 177 °C at 756 mm Hg |
| Refractive Index | n20/D 1.526 |
| Flash Point | 113 °F |
| Vapor Pressure | 2.8 mmHg at 25 °C |
Industrial Applications
This chemical serves as a fundamental precursor in multiple sectors. In the pharmaceutical industry, it is employed in the synthesis of active pharmaceutical ingredients (APIs) where fluorination is required to optimize drug performance. Additionally, it finds significant application in agrochemical research for developing novel pesticides and herbicides with improved environmental profiles. The stability of the carbon-fluorine bond ensures that the resulting molecules maintain their structural integrity under various physiological conditions.
- Pharmaceutical intermediate synthesis for novel therapeutics
- Agrochemical product development for crop protection
- Organic fluorescence material research and development
- Cross-coupling reaction substrate in catalytic processes
- Custom synthesis projects requiring halogenated building blocks
Quality Assurance and Safety
We adhere to strict quality control protocols throughout the production cycle. Each batch is accompanied by a Certificate of Analysis (COA) to verify compliance with specified parameters. Our laboratory equipment is calibrated regularly to ensure accurate measurement of purity, moisture content, and physical constants. This commitment to quality minimizes downstream processing issues for our clients.
Regarding safety, this product is classified as a flammable liquid (UN1993, Class 3). Proper handling procedures must be followed, including storage in cool, well-ventilated areas away from ignition sources. Personnel should utilize appropriate personal protective equipment during handling. Our packaging options include 25kg drums, utilizing plastic or plastic-coated iron drums to ensure integrity during global transit. We are committed to providing reliable supply chains for our global partners, supporting their R&D and manufacturing needs with timely delivery and competitive bulk pricing. Our logistics team ensures compliance with international transport regulations for hazardous chemicals.
