Intermediates

2-Bromo-5-trifluoromethylphenol

  • CAS No.402-05-1
  • GradeIndustrial / Pharmaceutical
  • Availability● In Stock

High-purity 2-Bromo-5-trifluoromethylphenol (CAS 402-05-1) designed for advanced pharmaceutical intermediate synthesis and organic chemistry applications.

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Product Technical Details

Product Overview

2-Bromo-5-trifluoromethylphenol represents a critical fluorinated building block within the realm of advanced organic synthesis and medicinal chemistry. This specialized intermediate is engineered to meet the rigorous demands of modern pharmaceutical research and development programs globally. The strategic incorporation of the trifluoromethyl group significantly enhances the metabolic stability and lipophilicity of downstream drug candidates, making this compound an invaluable asset for medicinal chemists seeking to optimize lead compounds. Our dedicated manufacturing process ensures consistent quality and high purity levels suitable for complex multi-step synthesis routes required in novel drug discovery.

As a leading global manufacturer of fine chemicals, we understand the paramount importance of reliability in the supply chain for research materials. This product undergoes stringent quality control protocols at every stage of production to guarantee performance. From raw material selection to final packaging, each batch is meticulously analyzed using advanced techniques such as HPLC and NMR to confirm compliance with international standards. We provide comprehensive documentation including Certificates of Analysis to fully support your regulatory filings and internal quality assurance requirements.

Technical Specifications

ParameterValue
CAS Number402-05-1
Molecular FormulaC7H4BrF3O
Molecular Weight241.00500
Purity≥98.0%
Boiling Point219ºC at 760mmHg
Density1.752g/cm3
Flash Point86.3ºC
Refractive Index1.505
AppearanceNot specified

Applications and Advantages

This fluorinated phenol derivative serves as a versatile precursor in the synthesis of various agrochemicals and pharmaceutical agents targeting diverse therapeutic areas. The presence of both bromine and trifluoromethyl functionalities allows for diverse chemical transformations including palladium-catalyzed cross-coupling reactions and nucleophilic aromatic substitutions. Researchers utilize this intermediate to introduce specific structural motifs that improve the bioavailability and potency of final active pharmaceutical ingredients. The robust nature of the carbon-fluorine bond ensures stability during subsequent synthetic steps.

  • High chemical stability under standard storage and handling conditions
  • Optimized for seamless scale-up from laboratory to industrial production
  • Compatible with a wide range of organic synthesis methodologies and catalysts
  • Supports rapid development cycles for new drug entities and patents
  • Backed by dedicated technical support from experienced synthetic chemists
  • Consistent batch-to-batch reproducibility for reliable research outcomes

Storage and Handling

To maintain optimal quality and safety, 2-Bromo-5-trifluoromethylphenol should be stored in a tightly closed container within a cool and dry environment away from incompatible materials. Protection from moisture and direct sunlight is strongly recommended to prevent any potential degradation over time. Proper handling procedures including the use of appropriate personal protective equipment are advised during transfer and processing operations. Our packaging solutions are designed to ensure product integrity during global shipping and long-term storage while complying with safety regulations.