Intermediates

2-Bromo-6-chloro-4-methylpyridine

  • CAS No.157329-89-0
  • GradeIndustrial / Pharmaceutical
  • Availability● In Stock

High-purity 2-Bromo-6-chloro-4-methylpyridine (CAS 157329-89-0) designed for advanced organic synthesis and pharmaceutical intermediate applications.

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Product Technical Details

Product Overview

2-Bromo-6-chloro-4-methylpyridine is a highly specialized halogenated pyridine derivative engineered for precision organic synthesis. As a critical building block in modern medicinal chemistry, this compound facilitates the construction of complex molecular architectures required for pharmaceutical development. Our manufacturing process ensures exceptional batch-to-batch consistency, making it an ideal choice for research laboratories and industrial production scales alike.

The strategic positioning of bromine and chlorine substituents on the pyridine ring provides versatile reactivity profiles. This allows chemists to perform selective cross-coupling reactions or nucleophilic substitutions with high efficiency. The presence of the methyl group further enhances the lipophilic characteristics, which is often desirable in drug design optimization.

Chemical Properties and Stability

This compound exhibits robust stability under standard storage conditions, maintaining its integrity over extended periods when handled correctly. The physical form typically presents as a white to light yellow powder, indicating high levels of purification. With a molecular weight of 206.47 g/mol and a defined boiling point, it integrates seamlessly into various synthetic workflows involving heat or solvent-based processes.

Our quality control laboratories rigorously test each batch to confirm physical constants such as density and refractive index. These parameters serve as critical indicators of purity and structural correctness, ensuring that the material performs predictably in downstream reactions.

Industrial Applications

Primarily utilized as an intermediate in organic synthesis, this pyridine derivative supports the development of active pharmaceutical ingredients (APIs). It is frequently employed in palladium-catalyzed coupling reactions, including Suzuki-Miyaura and Buchwald-Hartwig protocols. Additionally, it serves as a key precursor in the synthesis of agrochemicals and functional materials where heterocyclic structures are required.

  • Pharmaceutical intermediate for novel drug discovery
  • Reagent for cross-coupling reactions
  • Building block for agrochemical formulations
  • Component in advanced material science research

Specifications and Quality Assurance

We adhere to strict quality management systems to guarantee product reliability. Every shipment is accompanied by a Certificate of Analysis (COA) detailing comprehensive test results. Our commitment to industrial purity standards ensures minimal impurities that could interfere with sensitive catalytic processes.

ParameterSpecification
Chemical Name2-Bromo-6-chloro-4-methylpyridine
CAS Number157329-89-0
Molecular FormulaC6H5BrClN
Molecular Weight206.47 g/mol
Purity≥99.0%
AppearanceWhite to light yellow powder
Density1.625 g/cm3
Boiling Point261.91 °C
Flash Point112.20 °C

Packaging and Storage

To preserve quality during transit, the product is packaged in secure 25 kg drums. Custom packaging solutions are available upon request to meet specific logistical requirements. For optimal stability, store the material in a cool, ventilated area away from direct sunlight and moisture. Proper handling procedures should be followed to ensure safety and maintain chemical integrity throughout the supply chain.