2-Bromo-6-fluoro-4-methylpyridine

Product Overview

2-Bromo-6-fluoro-4-methylpyridine is a highly specialized heterocyclic building block designed for advanced medicinal chemistry applications. As a key fluorinated pyridine derivative, this compound serves as a critical intermediate in the synthesis of various pharmaceutical agents, particularly those targeting kinase inhibitors and central nervous system therapeutics. Our manufacturing process ensures exceptional batch-to-batch consistency, making it an ideal choice for research and development teams requiring reliable raw materials for complex organic synthesis.

We understand the stringent demands of the pharmaceutical industry. Therefore, every production run undergoes rigorous quality control protocols to guarantee high chemical purity and structural integrity. This product is supplied as a yellow liquid, ready for immediate use in cross-coupling reactions and nucleophilic substitutions.

Key Specifications

Chemical Properties

The physicochemical characteristics of 2-Bromo-6-fluoro-4-methylpyridine make it suitable for a wide range of reaction conditions. The presence of both bromine and fluorine substituents on the pyridine ring allows for selective functionalization, enabling chemists to construct diverse molecular architectures efficiently. The compound exhibits a density of approximately 1.6 g/cm3 and a boiling point of 230.8 °C at 760 mmHg. Its refractive index is measured at 1.530, providing a reliable metric for identity confirmation during quality assurance testing.

Safety handling is paramount when working with halogenated pyridines. The flash point is recorded at 93.4 °C, indicating standard flammability precautions should be observed during storage and transfer. Proper ventilation and personal protective equipment are recommended to ensure laboratory safety compliance.

Industrial Applications

This intermediate is predominantly utilized in the development of new drug entities. Its structure facilitates palladium-catalyzed coupling reactions, which are fundamental in modern drug discovery pipelines. Researchers often employ this building block to introduce specific heterocyclic motifs into lead compounds, enhancing potency and metabolic stability. Beyond pharmaceuticals, it may also find applications in agrochemical research where fluorinated heterocycles are valued for their biological activity.

Quality Assurance and Storage

We commit to delivering products that meet international quality standards. Each shipment is accompanied by a Certificate of Analysis (COA) detailing test results for purity, identity, and physical properties. To maintain stability, store the container in a tightly closed condition within a cool, dry environment away from direct sunlight and moisture. Avoid contact with strong oxidizing agents. For large-scale production needs, we offer flexible packaging solutions and competitive bulk pricing to support your manufacturing goals.