2-Bromo-6-fluorophenol
- CAS No.2040-89-3
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High-purity 2-Bromo-6-fluorophenol (CAS 2040-89-3), a versatile halogenated aromatic intermediate for advanced organic synthesis.
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Product Overview
2-Bromo-6-fluorophenol is a high-value halogenated aromatic compound widely employed as a key building block in the pharmaceutical, agrochemical, and fine chemical industries. With its dual functionality—featuring both bromo and fluoro substituents in ortho positions—it offers exceptional regioselectivity for cross-coupling reactions, nucleophilic substitutions, and directed ortho-metalation strategies. This intermediate enables efficient construction of complex molecular architectures under controlled synthetic conditions.
Specifications
| Molecular Formula | C6H4BrFO |
|---|---|
| Molecular Weight | 190.998 g/mol |
| CAS Number | 2040-89-3 |
| Appearance | White to off-white powder |
| Assay | ≥98.0% |
| Density | 1.8 ± 0.1 g/cm³ |
| Boiling Point | 173.0 ± 20.0 °C at 760 mmHg |
| Flash Point | 58.4 ± 21.8 °C |
| Vapour Pressure | 1.0 ± 0.3 mmHg at 25°C |
| Refractive Index | 1.576 |
Industrial Applications
As a specialized aromatic intermediate, 2-Bromo-6-fluorophenol serves critical roles in multi-step syntheses where precise functional group manipulation is required. Its primary utility lies in:
- Facilitating Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions due to the reactive C–Br bond.
- Acting as a precursor for fluorinated biaryl systems used in medicinal chemistry scaffolds.
- Enabling the synthesis of heterocyclic compounds through intramolecular cyclization pathways.
- Supporting the development of novel agrochemical actives requiring ortho-halogenated phenolic motifs.
Stored in a cool, well-ventilated area away from incompatible materials, this compound maintains stability under standard industrial handling protocols. Packaged in 25 kg drums or customized containers upon request, it meets stringent quality control standards for global B2B supply chains.
