Intermediates

2-Bromo-m-xylene

  • CAS No.576-22-7
  • GradeIndustrial / Pharmaceutical
  • Availability● In Stock

High purity 2-Bromo-m-xylene (CAS 576-22-7) is a colorless liquid intermediate designed for advanced organic synthesis and pharmaceutical manufacturing processes.

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Product Technical Details

Product Overview

2-Bromo-m-xylene, also known systematically as 2-Bromo-1,3-dimethylbenzene, is a specialized aryl halide compound that serves as a critical building block in modern organic chemistry. This colorless transparent liquid is characterized by its high reactivity due to the presence of the bromine substituent on the aromatic ring, making it an invaluable precursor for various cross-coupling reactions. Our manufacturing process ensures exceptional purity levels, typically exceeding 98.0 percent, which is essential for minimizing side reactions in downstream synthetic pathways.

As a key member of the bromoxylene family, this chemical exhibits stable physical properties under standard storage conditions while maintaining the necessary chemical lability for catalytic transformations. It is widely utilized by research laboratories and industrial production facilities alike for the construction of complex molecular architectures found in pharmaceuticals, agrochemicals, and advanced materials.

Technical Specifications

We adhere to strict quality control protocols to guarantee consistency across every batch. The following table outlines the key physicochemical properties and specification standards for our premium grade 2-Bromo-m-xylene.

Parameter Specification
CAS Number 576-22-7
Molecular Formula C8H9Br
Molecular Weight 185.061 g/mol
Appearance Colorless transparent liquid
Purity (Assay) ≥98.0%
Boiling Point 204.4±9.0 °C at 760 mmHg
Melting Point −10 °C
Density 1.3±0.1 g/cm3
Refractive Index 1.544
Flash Point 73.9±0.0 °C

Industrial Applications

The primary utility of 2-Bromo-m-xylene lies in its role as a versatile intermediate for organic synthesis. The bromine atom at the ortho position relative to the methyl groups facilitates specific regioselective reactions. It is extensively employed in palladium-catalyzed cross-coupling reactions, such as Suzuki-Miyaura, Heck, and Sonogashira couplings. These reactions are fundamental in the synthesis of biaryl structures, which are prevalent motifs in many active pharmaceutical ingredients (APIs).

Furthermore, this compound is utilized in the development of agrochemicals where specific substitution patterns on the benzene ring are required to achieve desired biological activity. In the materials science sector, it serves as a monomer or modifier in the production of specialized polymers and organic electronic materials. The high industrial purity provided by our manufacturing process ensures that catalyst poisoning is minimized, leading to higher yields and reduced waste in large-scale production environments.

Quality Assurance and Storage

Every shipment of 2-Bromo-m-xylene is accompanied by a comprehensive Certificate of Analysis (COA) and Material Safety Data Sheet (MSDS). Our quality assurance team performs rigorous testing using gas chromatography and other analytical methods to verify identity and purity. We recommend storing this product in a cool, ventilated place away from direct sunlight and sources of ignition. Containers should be kept tightly closed when not in use to prevent moisture absorption or contamination. Proper handling procedures should be followed, including the use of appropriate personal protective equipment, as the compound is flammable and may cause irritation.