2-Bromoterephthalic Acid
- CAS No.586-35-6
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High-purity 2-Bromoterephthalic acid (CAS 586-35-6), a key pharmaceutical intermediate for advanced organic synthesis.
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Product Overview
2-Bromoterephthalic acid is a high-value aromatic carboxylic acid derivative widely employed as a critical building block in the synthesis of complex pharmaceutical active ingredients. With a bromine substituent at the 2-position of the terephthalic acid backbone, this compound offers excellent regioselectivity for cross-coupling reactions, making it indispensable in modern medicinal chemistry workflows.
Specifications
| Molecular Formula | C8H5BrO4 |
|---|---|
| Molecular Weight | 245.03 g/mol |
| CAS Number | 586-35-6 |
| Appearance | White powder |
| Purity (GC) | ≥99.0% |
| Melting Point | 295–297°C |
| Density | 1.875 g/cm³ |
| Boiling Point | 421.6°C |
| Flash Point | 208.7°C |
| HS Code | 2914690090 |
| UN Number | UN2811 |
| Hazard Class | 6.1 |
| Packing Group | II |
Industrial Applications
This compound serves primarily as a synthetic intermediate in the production of sodium-glucose cotransporter 2 (SGLT2) inhibitors, notably in the manufacturing pathway of Tofogliflozin. Its dual carboxylic acid functionality and ortho-bromo group enable sequential functionalization via esterification, amidation, or palladium-catalyzed coupling reactions. Key advantages include:
- High regiochemical control for selective derivatization
- Excellent thermal stability under standard processing conditions
- Compatibility with large-scale GMP-compliant synthesis protocols
Stored in a cool, well-ventilated area away from incompatible materials, 2-Bromoterephthalic acid is typically supplied in 25 kg fiber drums, with custom packaging available upon request. Note: Supply is restricted in jurisdictions where relevant patents are in force.
