Intermediates

2-Butyl-5-nitrobenzofuran

  • CAS No.133238-87-6
  • GradeIndustrial / Pharmaceutical
  • Availability● In Stock

High-purity pharmaceutical intermediate used in the synthesis of Dronedarone. Available in bulk quantities with strict quality control and global shipping.

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Product Technical Details

Product Overview

2-Butyl-5-nitrobenzofuran represents a critical specialized organic intermediate within the modern pharmaceutical manufacturing landscape. Designed specifically for complex synthetic pathways, this compound serves as a foundational building block in the production of advanced cardiovascular therapeutic agents. Our facility maintains rigorous production standards to ensure that every batch meets the exacting requirements of global pharmaceutical clients. The chemical structure features a nitro-substituted benzofuran core, which provides unique reactivity profiles essential for downstream coupling reactions.

As a seasoned manufacturer with two decades of industry experience, we understand the importance of consistency in molecular architecture. This product is engineered to facilitate efficient synthesis routes, minimizing impurities that could complicate subsequent reaction steps. The high level of purification ensures that researchers and production teams can rely on consistent performance across large-scale manufacturing campaigns. We prioritize supply chain stability to support continuous production schedules for our partners.

Technical Specifications

The physical and chemical properties of this intermediate are tightly controlled to guarantee optimal performance during synthesis. Below is a detailed breakdown of the key parameters that define the quality of our supply. These specifications are verified through advanced analytical methods including High-Performance Liquid Chromatography (HPLC) and Nuclear Magnetic Resonance (NMR) spectroscopy to ensure accuracy.

ParameterValue
CAS Number133238-87-6
Molecular FormulaC12H13NO3
Molecular Weight219.24 g/mol
AppearanceBright Yellow Low Melting Solid
Purity≥98.0%
Density1.2±0.1 g/cm3
Boiling Point329.7±22.0 °C
Flash Point153.2±22.3 °C
Refractive Index1.586

Industrial Applications

This compound is primarily utilized as a key precursor in the synthesis of Dronedarone and its hydrochloride salt. These final active pharmaceutical ingredients are vital in the management of specific cardiac arrhythmias. The nitro group on the benzofuran ring allows for specific reduction and functionalization steps required to construct the final drug molecule. Our clients in the pharmaceutical sector rely on this intermediate to maintain supply chain stability for their finished dosage forms.

Beyond its primary application, this benzofuran derivative may serve as a valuable reference standard or research chemical in organic synthesis laboratories focusing on heterocyclic chemistry. The robust stability of the molecule under standard storage conditions makes it suitable for international logistics and long-term inventory management. Our production capacity allows for scalable supply to meet fluctuating market demands without compromising on quality metrics.

Quality Assurance and Storage

We adhere to strict quality management systems to ensure product integrity from synthesis to delivery. Each shipment is accompanied by a comprehensive Certificate of Analysis (COA) detailing batch-specific test results. Proper storage is essential to maintain the chemical stability of this nitro-substituted compound. We recommend storing the material in a cool, dry, and well-closed container, protected from moisture and strong light or heat sources.

Handling precautions should follow standard laboratory safety protocols. Personnel should utilize appropriate personal protective equipment including gloves and safety goggles when manipulating the solid form. Packaging options include 25kg cardboard drums or customized solutions based on specific client requirements. Our logistics team ensures safe handling and compliance with international shipping regulations for fine chemicals. By choosing our supply, partners gain access to reliable volumes, technical support, and a commitment to excellence that defines our twenty-year legacy in the chemical industry.