2-Chloro-1-((3-fluorobenzyl)oxy)-4-nitrobenzene
- CAS No.443882-99-3
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High purity pharmaceutical intermediate used primarily in the synthesis of kinase inhibitors such as Lapatinib. Available in bulk quantities with comprehensive quality documentation.
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Product Overview
2-Chloro-1-((3-fluorobenzyl)oxy)-4-nitrobenzene is a specialized fluorinated organic compound serving as a critical building block in modern pharmaceutical synthesis. This nitrobenzene derivative is engineered for high reactivity and stability, making it an essential precursor in the manufacturing of advanced therapeutic agents. Our production facilities adhere to strict quality management systems to ensure consistent molecular integrity and purity levels suitable for complex multi-step synthesis routes.
As a key intermediate in the production of Lapatinib, a potent kinase inhibitor used in oncology treatments, this compound plays a vital role in the global supply chain for cancer therapeutics. The presence of both chloro and fluoro substituents on the benzene ring provides unique electronic properties that facilitate specific nucleophilic substitution reactions required in downstream API manufacturing.
Technical Specifications
| Parameter | Specification |
|---|---|
| CAS Number | 443882-99-3 |
| Molecular Formula | C13H9ClFNO3 |
| Molecular Weight | 281.67 g/mol |
| Appearance | White Powder |
| Purity | ≥99.0% |
| Density | 1.393 g/cm3 |
| Boiling Point | 400.5°C at 760 mmHg |
| Flash Point | 196.0±25.9 °C |
| Refractive Index | 1.596 |
| Residue on Ignition | ≤0.001% |
| Heavy Metals | ≤0.005% |
| Moisture Content | ≤1.0% |
Industrial Applications
This chemical intermediate is primarily utilized in the pharmaceutical industry for the synthesis of tyrosine kinase inhibitors. Its specific structural configuration allows for precise coupling reactions necessary to construct the core framework of targeted cancer therapies. Beyond oncology, fluorinated nitrobenzene derivatives are increasingly valuable in the development of novel agrochemicals and specialized materials where thermal stability and chemical resistance are paramount.
Researchers and process chemists value this compound for its reliable performance in nucleophilic aromatic substitution processes. The high purity grade ensures minimal byproduct formation during scale-up, reducing purification costs and improving overall yield in final API production.
Quality Assurance and Packaging
Every batch undergoes rigorous analytical testing including HPLC, GC-MS, and NMR spectroscopy to verify structural identity and purity profiles. We provide a comprehensive Certificate of Analysis (COA) with each shipment, detailing all critical quality attributes. Our commitment to quality extends to our packaging solutions, which are designed to maintain product stability during international transit.
- Standard Packaging: 25kg cardboard drums
- Custom Packaging: Available upon request
- Storage Conditions: Cool, dry, well-closed container
- Protection: Keep away from moisture and strong light or heat
As a global manufacturer, we offer competitive bulk pricing and reliable logistics support to ensure uninterrupted supply for your production lines. Contact our technical sales team for detailed synthesis routes, safety data sheets, and sample availability.
