2-Chloro-1,4-naphthoquinone
- CAS No.1010-60-2
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High-purity 2-Chloro-1,4-naphthoquinone (CAS 1010-60-2) is a critical pharmaceutical intermediate used primarily in the synthesis of antimalarial agents like Atovaquone.
Request Bulk PricingProduct Technical Details
Product Overview
2-Chloro-1,4-naphthoquinone is a specialized organic compound recognized for its significant role in medicinal chemistry and advanced organic synthesis. As a chlorinated derivative of 1,4-naphthoquinone, this chemical serves as a vital building block for constructing complex pharmaceutical architectures. Our facility produces this intermediate under strict quality control protocols to ensure consistency and reliability for downstream manufacturing processes.
The compound is characterized by its distinct yellow crystalline structure and high reactivity, making it an ideal candidate for nucleophilic substitution reactions. We prioritize industrial purity standards to minimize impurities that could affect subsequent synthesis steps, ensuring optimal yield and performance for our global partners.
Technical Specifications
| Parameter | Specification |
|---|---|
| CAS Number | 1010-60-2 |
| Molecular Formula | C10H5ClO2 |
| Molecular Weight | 192.60 g/mol |
| Appearance | Yellow crystalline powder |
| Purity | ≥98.0% |
| Loss on Drying | ≤0.5% |
| Boiling Point | 308°C at 760 mmHg |
| Flash Point | 129.3°C |
| Density | 1.42 g/cm3 |
Industrial Applications
This chemical intermediate is predominantly utilized in the pharmaceutical sector. Its primary application lies in the synthesis of antimalarial medications, specifically serving as a key precursor for Atovaquone. The high reactivity of the chloro group allows for efficient coupling reactions necessary to build the target active pharmaceutical ingredient (API).
Beyond pharmaceuticals, 2-Chloro-1,4-naphthoquinone finds utility in research and development laboratories focusing on organic electronics and dye chemistry. The quinone structure provides unique electrochemical properties valuable for specialized material science applications. Our manufacturing process is designed to support both large-scale production runs and custom synthesis requirements for research purposes.
Quality Assurance and Handling
Quality is paramount in our production line. Each batch undergoes rigorous testing using High-Performance Liquid Chromatography (HPLC) and Nuclear Magnetic Resonance (NMR) spectroscopy to verify structural integrity and purity levels. We provide a comprehensive Certificate of Analysis (COA) with every shipment to document compliance with specified standards.
- Strict impurity profiling to ensure ≤2.0% total impurities.
- Controlled manufacturing environment to prevent moisture absorption.
- Batch traceability for full supply chain transparency.
For safe handling, personnel should utilize appropriate personal protective equipment (PPE), including gloves and safety goggles. The product should be stored in a cool, dry, and well-ventilated area, kept away from strong light and heat sources to maintain stability. Packaging is available in 25kg cardboard drums or customized according to specific logistical requirements.
