Intermediates

2-Chloro-1-cyclopropyl-2-(2-fluorophenyl)ethanone

  • CAS No.178688-43-2
  • GradeIndustrial / Pharmaceutical
  • Availability● In Stock

High-purity pharmaceutical intermediate for Prasugrel synthesis. Available in bulk quantities with full COA and global shipping capabilities.

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Product Technical Details

Product Overview

2-Chloro-1-cyclopropyl-2-(2-fluorophenyl)ethanone is a specialized pharmaceutical intermediate characterized by its high chemical stability and specific reactivity profile. Identified by CAS number 178688-43-2, this compound serves as a critical building block in the synthesis of advanced therapeutic agents, particularly within the cardiovascular sector. Our manufacturing process ensures consistent quality suitable for large-scale pharmaceutical production and research applications.

This ketone derivative features a unique structural arrangement involving a cyclopropyl group and a fluorophenyl moiety. Such structural features are essential for achieving the desired biological activity in downstream drug formulations. The introduction of fluorine atoms often enhances metabolic stability and bioavailability in medicinal chemistry. We prioritize purity and structural integrity to support efficient synthesis routes and minimize downstream purification challenges.

Technical Specifications

ParameterValue
Chemical Name2-Chloro-1-cyclopropyl-2-(2-fluorophenyl)ethanone
CAS Number178688-43-2
Molecular FormulaC11H10ClFO
Molecular Weight212.65 g/mol
AppearanceWhite to off-white crystalline powder
Purity≥99.0%
Boiling Point274.06°C at 760 mmHg
Density1.316 g/cm3
Flash Point119.55°C

Industrial Applications

The primary application of this compound lies within the pharmaceutical sector, specifically as a key intermediate in the manufacturing of Prasugrel hydrochloride. Prasugrel is a well-known antiplatelet medication used to prevent thrombotic cardiovascular events in patients with acute coronary syndromes. The precision required in synthesizing such medications demands intermediates of the highest caliber to ensure patient safety and drug efficacy.

Beyond specific drug synthesis, this chemical is utilized in various organic synthesis pathways where fluorinated ketones are required. Its reactivity profile allows for versatile functionalization, making it a valuable asset for research and development teams focusing on novel cardiovascular therapies. The robustness of the chloro and fluoro substituents provides excellent handles for further chemical transformations during multi-step synthesis processes.

Quality Assurance and Packaging

Quality control is paramount in our production facility. Each batch undergoes rigorous testing using high-performance liquid chromatography (HPLC) and nuclear magnetic resonance (NMR) spectroscopy. We guarantee that moisture content and impurity levels remain within strict limits to ensure process safety and yield efficiency. Our quality management system adheres to international standards to provide reliability.

  • Comprehensive Certificate of Analysis (COA) provided with every shipment.
  • Batch tracking systems for full traceability from raw materials to finished goods.
  • Custom packaging solutions available upon request to meet specific logistical needs.
  • Regular stability testing to ensure shelf-life integrity.

Standard packaging consists of 25kg cardboard drums, designed to protect the product from environmental factors such as moisture and physical damage. For larger industrial requirements, we offer flexible packing options tailored to logistical needs and customer specifications. This ensures that the material arrives in optimal condition regardless of the destination.

Storage and Handling

To maintain optimal stability, store this material in a cool, dry, and well-ventilated area. Containers must remain tightly closed to prevent moisture absorption and exposure to strong light or heat sources. Proper handling procedures should be followed in accordance with standard laboratory safety protocols and local regulations regarding chemical storage.

Our commitment to excellence ensures that clients receive reliable materials that streamline their production timelines. Partner with us for a secure supply chain of premium pharmaceutical intermediates. We support global distribution with efficient logistics to minimize lead times and support your manufacturing continuity.