Intermediates

2-Chloro-3,6-Difluorobenzaldehyde

  • CAS No.261762-39-4
  • GradeIndustrial / Pharmaceutical
  • Availability● In Stock

High-purity 2-Chloro-3,6-Difluorobenzaldehyde (CAS 261762-39-4) is a critical fluorinated intermediate designed for advanced organic synthesis and pharmaceutical manufacturing processes.

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Product Technical Details

Product Overview

2-Chloro-3,6-Difluorobenzaldehyde represents a highly specialized fluorinated building block essential for modern medicinal chemistry and agrochemical development. As a key intermediate, this compound features a unique substitution pattern on the benzene ring, incorporating both chlorine and fluorine atoms which significantly enhance the metabolic stability and lipophilicity of downstream pharmaceutical candidates. Our manufacturing process ensures consistent quality and reliability for research and industrial scale applications.

The strategic placement of halogen atoms allows for versatile chemical transformations, including nucleophilic aromatic substitution and cross-coupling reactions. This makes the material indispensable for synthesizing complex heterocyclic structures found in numerous therapeutic classes. We prioritize strict quality control measures to guarantee that every batch meets the rigorous demands of global pharmaceutical supply chains.

Key Specifications

Quality assurance is paramount in the production of fine chemical intermediates. Our facility utilizes advanced gas chromatography and spectroscopic methods to verify identity and purity. The following table outlines the critical physical and chemical parameters associated with this product.

ParameterSpecification
Chemical Name2-Chloro-3,6-Difluorobenzaldehyde
CAS Number261762-39-4
Molecular FormulaC7H3ClF2O
Molecular Weight176.55 g/mol
AppearanceWhite to yellow crystalline powder
Purity (GC)≥99.0%
Melting Point46-50°C
Boiling Point206.4°C
Density1.453 g/cm³
Refractive Index1.536

Industrial Applications

This fluorinated aldehyde serves as a vital precursor in the synthesis of active pharmaceutical ingredients (APIs). The presence of fluorine atoms often improves the bioavailability and binding affinity of drug molecules to their target receptors. Consequently, this intermediate is frequently employed in the development of novel treatments for neurological disorders, oncology, and infectious diseases.

Beyond pharmaceuticals, the compound finds utility in the agrochemical sector where fluorinated structures enhance pesticide efficacy and environmental stability. Organic chemists utilize this building block for constructing complex molecular architectures through various catalytic processes. Its high purity level ensures minimal byproduct formation during subsequent synthetic steps, optimizing overall yield and reducing purification costs.

Storage and Handling

Proper storage conditions are essential to maintain the integrity of 2-Chloro-3,6-Difluorobenzaldehyde. The material should be kept in a cool, well-ventilated area away from direct sunlight and moisture sources. Containers must remain tightly sealed when not in use to prevent degradation or contamination. We recommend storing the product in its original packaging until ready for use.

Safety protocols dictate that handling should occur in a fume hood with appropriate personal protective equipment, including gloves and safety goggles. In case of spillage, standard chemical cleanup procedures should be followed immediately. Our team provides comprehensive technical support and documentation, including Certificates of Analysis (COA), to ensure compliance with your internal quality standards and regulatory requirements.