2-Chloro-3-amino-4-methylpyridine
- CAS No.133627-45-9
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High-purity 2-Chloro-3-amino-4-methylpyridine (CAS 133627-45-9) for pharmaceutical synthesis. Reliable bulk supply with comprehensive COA.
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Product Overview
2-Chloro-3-amino-4-methylpyridine is a specialized heterocyclic organic compound designed for advanced pharmaceutical synthesis. As a critical building block, this chemical features a unique pyridine backbone substituted with chloro, amino, and methyl functional groups. These structural elements provide exceptional reactivity, making it an indispensable precursor in the manufacturing of complex active pharmaceutical ingredients (APIs). Our facility ensures that every batch meets rigorous international standards for purity and consistency.
This compound is particularly valued in medicinal chemistry for its versatility in coupling reactions. The presence of the amino group allows for facile derivatization, while the chloro substituent enables nucleophilic substitution strategies. This dual functionality supports the construction of sophisticated molecular architectures required in modern drug discovery and development pipelines.
Technical Specifications
We maintain strict quality control protocols to guarantee the performance of our chemical intermediates. The following table outlines the key physical and chemical properties verified through our analytical laboratories.
| Parameter | Value |
|---|---|
| CAS Number | 133627-45-9 |
| Molecular Formula | C6H7ClN2 |
| Molecular Weight | 142.59 g/mol |
| Appearance | Yellowish powder |
| Purity | ≥99.0% |
| Melting Point | 61-64 °C |
| Boiling Point | 283.3 °C at 760 mmHg |
| Density | 1.26 g/cm3 |
| Flash Point | 125.2 °C |
| Refractive Index | 1.592 |
| Moisture Content | <0.04% |
| Heavy Metals | <0.002% |
Industrial Applications
The primary application of 2-Chloro-3-amino-4-methylpyridine lies in the pharmaceutical sector. It serves as a key intermediate in the synthesis of antiretroviral medications. Specifically, it is utilized in the production pathways for complex therapeutics requiring precise heterocyclic scaffolds. Beyond pharmaceuticals, this compound may find utility in agrochemical research and fine chemical synthesis where substituted pyridines are required.
Our clients leverage this intermediate for scale-up processes due to its stable physical properties and high reactivity profile. The low moisture content and minimal heavy metal contamination ensure that downstream reactions proceed without interference, reducing waste and improving overall yield in final API manufacturing.
Quality Assurance and Packaging
Quality is the cornerstone of our manufacturing process. Each production lot undergoes comprehensive testing using HPLC, GC-MS, and NMR spectroscopy to confirm identity and purity. We provide a Certificate of Analysis (COA) with every shipment, detailing all test results against specifications. Our packaging solutions are designed to maintain product integrity during global transit.
- Standard Packaging: 25kg cardboard drums.
- Custom Packaging: Available according to customer specified requirements.
- Labeling: Clear identification with CAS number and batch code.
- Documentation: Full regulatory support documents provided upon request.
Storage and Handling
To preserve the chemical stability of 2-Chloro-3-amino-4-methylpyridine, proper storage conditions are essential. The product should be stored in a tightly closed container to prevent moisture absorption and oxidation. Facilities must be cool, dry, and well-ventilated, away from incompatible substances such as strong oxidizing agents. Personnel handling this material should adhere to standard industrial hygiene practices, including the use of appropriate personal protective equipment (PPE) to ensure safety during weighing and transfer operations.
