2-Chloro-3-Fluoro-6-Picoline
- CAS No.374633-32-6
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High-purity 2-Chloro-3-Fluoro-6-Picoline (CAS 374633-32-6) designed for advanced pharmaceutical intermediate synthesis with guaranteed quality.
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Product Overview
2-Chloro-3-Fluoro-6-Picoline is a highly specialized halogenated pyridine derivative that serves as a vital building block in modern medicinal chemistry and organic synthesis. Characterized by its unique substitution pattern featuring both chlorine and fluorine atoms on the pyridine ring, this compound offers exceptional reactivity for various cross-coupling reactions and nucleophilic substitutions. Our facility produces this chemical intermediate under strict quality control standards to ensure consistency and reliability for downstream pharmaceutical applications.
The strategic incorporation of fluorine and chlorine substituents enhances the metabolic stability and bioavailability of final drug candidates, making this picoline derivative a preferred choice for research and development teams focused on novel therapeutic agents. We are committed to supplying global clients with premium-grade materials that meet rigorous industry specifications.
Key Specifications
| Parameter | Value |
|---|---|
| Chemical Name | 2-Chloro-3-Fluoro-6-Picoline |
| CAS Number | 374633-32-6 |
| Molecular Formula | C6H5ClFN |
| Molecular Weight | 145.56 g/mol |
| Appearance | Light yellow crystal |
| Purity | ≥98.0% |
| Density | 1.3±0.1 g/cm3 |
| Boiling Point | 167.8±35.0 °C at 760 mmHg |
| Flash Point | 55.3±25.9 °C |
| Refractive Index | 1.504 |
Industrial Applications
This fluorinated pyridine derivative is extensively utilized in the synthesis of complex pharmaceutical intermediates. Its chemical structure allows for versatile functionalization, enabling chemists to construct diverse molecular architectures required for kinase inhibitors, agrochemicals, and advanced organic materials. The presence of the chloro group facilitates palladium-catalyzed coupling reactions, while the fluoro group provides electronic modulation essential for optimizing biological activity.
Researchers value this compound for its stability and predictable reactivity profiles. It is commonly employed in multi-step synthesis routes where high purity is critical to prevent side reactions and ensure optimal yield in final API production. Our manufacturing process is optimized to deliver consistent batch-to-bquality, supporting large-scale production needs.
Quality Assurance and Storage
We maintain a robust quality management system to guarantee the integrity of every shipment. Each batch undergoes comprehensive analytical testing, including HPLC and NMR spectroscopy, to verify identity and purity levels. A Certificate of Analysis (COA) is provided with every order to document compliance with specified parameters.
- Packaged in 25 KGS drums for secure transportation.
- Store in a tightly closed container to prevent moisture absorption.
- Keep in a cool, dry, and well-ventilated area away from incompatible substances.
- Handle with appropriate personal protective equipment during usage.
- Global shipping available with reliable logistics partners.
Our team of technical experts is available to support your synthesis projects with detailed documentation and custom manufacturing solutions. Contact us today to discuss your requirements for 2-Chloro-3-Fluoro-6-Picoline and secure a reliable supply chain for your critical operations.
