Intermediates

2-Chloro-3-fluoroaniline

  • CAS No.21397-08-0
  • GradeIndustrial / Pharmaceutical
  • Availability● In Stock

High-purity 2-Chloro-3-fluoroaniline (CAS 21397-08-0) designed for advanced organic synthesis. Reliable supply for pharmaceutical and agrochemical intermediate production.

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Product Technical Details

Product Overview

2-Chloro-3-fluoroaniline is a specialized halogenated aromatic amine designed for complex organic synthesis workflows. As a critical building block in modern medicinal chemistry, this compound features both chloro and fluoro substituents on the benzene ring, offering unique reactivity profiles for nucleophilic substitution and cross-coupling reactions. Our manufacturing process ensures high consistency and reliability for large-scale industrial applications. The strategic placement of halogen atoms allows chemists to utilize this intermediate in the development of advanced pharmaceutical agents and agrochemical formulations. We prioritize strict quality control measures to guarantee that every batch meets the rigorous demands of research and production environments.

Technical Specifications

ParameterValue
CAS Number21397-08-0
Molecular FormulaC6H5ClFN
Molecular Weight145.56 g/mol
AppearanceColorless to Light Yellow Liquid
Purity≥98.0%
Packing25kg/Drum

Physical and Chemical Properties

Understanding the physical characteristics of 2-Chloro-3-fluoroaniline is essential for safe handling and process optimization. The compound exhibits a density of approximately 1.349 g/mL at 25 degrees Celsius, indicating a relatively heavy liquid structure typical of halogenated organics. With a boiling point of 210.3 degrees Celsius at 760 mmHg, it demonstrates thermal stability suitable for various reaction conditions. The flash point is recorded at 81 degrees Celsius, necessitating standard flammable liquid storage protocols. Additionally, the refractive index of 1.592 serves as a key identifier for purity verification during incoming quality assurance checks. These properties collectively define the handling requirements and potential synthesis pathways available to process chemists.

Industrial Applications

This fluorinated aniline derivative serves as a versatile intermediate in the production of high-value chemicals. Primary applications include pharmaceutical intermediate synthesis where it is used in constructing complex heterocyclic structures. It acts as a precursor for novel herbicides and pesticides in agrochemical development. In material science, it is utilized in the creation of specialized polymers and organic materials. The presence of fluorine often enhances metabolic stability and bioavailability in drug candidates, making this raw material highly valuable. Our global supply chain supports R&D laboratories and manufacturing facilities alike, ensuring timely delivery of this essential raw material for diverse synthetic routes.

Quality Assurance and Logistics

We maintain a robust quality management system to ensure product integrity from synthesis to shipment. Each batch undergoes rigorous testing using GC and HPLC methods to confirm purity levels exceeding 98 percent. To maintain product stability, store in a tightly closed container within a cool, dry, and well-ventilated area. Keep away from incompatible substances such as strong oxidizing agents. Always refer to the Safety Data Sheet for comprehensive handling guidelines. We provide full documentation including Certificate of Analysis and MSDS with every shipment to ensure regulatory compliance. Our logistics team supports global shipping options, accommodating bulk orders with secure packaging to prevent leakage or contamination during transit.