Intermediates

2-Chloro-4-methoxy-5-nitropyridine

  • CAS No.607373-83-1
  • GradeIndustrial / Pharmaceutical
  • Availability● In Stock

High-purity 2-Chloro-4-methoxy-5-nitropyridine (CAS 607373-83-1), a key pyridine-based intermediate for advanced organic synthesis in pharmaceutical and agrochemical manufacturing.

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Product Technical Details

Product Overview

2-Chloro-4-methoxy-5-nitropyridine is a high-value heterocyclic building block widely employed as an intermediate in the synthesis of complex organic molecules. With its distinctive substitution pattern—featuring chlorine, methoxy, and nitro functional groups on the pyridine ring—it offers versatile reactivity for nucleophilic aromatic substitution, cross-coupling reactions, and further derivatization. This compound is particularly valuable in the development of active pharmaceutical ingredients (APIs) and crop protection agents where precise molecular architecture is critical.

Specifications

Molecular FormulaC6H5ClN2O3
Molecular Weight188.57 g/mol
CAS Number607373-83-1
AppearanceYellow crystalline powder
Assay (GC/HPLC)≥98.0%
Density1.4 ± 0.1 g/cm³
Boiling Point311.6 ± 37.0 °C at 760 mmHg
Flash Point142.3 ± 26.5 °C
Vapour Pressure0.0 ± 0.6 mmHg at 25 °C
Refractive Index1.565

Industrial Applications

As a specialized pyridine derivative, 2-Chloro-4-methoxy-5-nitropyridine serves primarily as a synthetic intermediate in multi-step organic transformations. Its robust electrophilic character enables efficient construction of C–N, C–O, and C–C bonds under controlled conditions. Key application sectors include:

  • Pharmaceutical R&D for novel therapeutic scaffolds
  • Agrochemical innovation targeting selective bioactivity
  • Fine chemical manufacturing requiring regioselective functionalization

Our product is manufactured under stringent quality control protocols to ensure batch-to-batch consistency, full traceability, and compliance with international regulatory standards. Packaging is available in standard 25 kg drums or customized configurations upon request. Store in a cool, dry, and well-ventilated area away from incompatible materials.