Intermediates

2-Chloro-4-(piperidin-1-ylmethyl)pyridine

  • CAS No.146270-01-1
  • GradeIndustrial / Pharmaceutical
  • Availability● In Stock

High purity 2-Chloro-4-(piperidin-1-ylmethyl)pyridine is a key pharmaceutical intermediate designed for advanced organic synthesis and drug discovery applications.

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Product Technical Details

Product Overview

2-Chloro-4-(piperidin-1-ylmethyl)pyridine represents a sophisticated heterocyclic building block essential for modern medicinal chemistry. This compound features a pyridine core substituted with a chloro group and a piperidinylmethyl moiety, offering unique reactivity profiles for complex molecular construction. As a critical intermediate, it serves as a foundational element in the synthesis of various therapeutic agents, enabling chemists to introduce specific nitrogen-containing structures into target molecules.

Our manufacturing process ensures exceptional consistency and quality, adhering to strict industrial standards. The compound is characterized by its stability and solubility properties, making it highly suitable for diverse reaction conditions including nucleophilic substitutions and cross-coupling reactions. We prioritize safety and compliance throughout production, delivering a reliable raw material for research and development teams worldwide.

Technical Specifications

ParameterValue
CAS Number146270-01-1
Molecular FormulaC11H15ClN2
Molecular Weight210.70 g/mol
AppearanceWhite powder
Purity≥98.0%
Density1.164 g/mL at 25 °C
Boiling Point303.789 °C at 760 mmHg
Flash Point137.527 °C
Refractive Indexn20/D 1.563

Applications in Pharmaceutical Synthesis

This pyridine derivative is extensively utilized in the development of novel pharmaceutical compounds. The chloro substituent provides a reactive site for further functionalization, allowing for the introduction of diverse chemical groups through catalytic processes. The piperidine ring enhances the basicity and solubility of the final drug candidates, which is often crucial for bioavailability and pharmacokinetic profiles.

Researchers employ this intermediate in the synthesis of kinase inhibitors, receptor modulators, and other biologically active molecules. Its robust chemical structure withstands rigorous synthetic conditions, ensuring high yields in multi-step synthesis routes. Whether used in early-stage drug discovery or process development for scale-up, this material supports the creation of next-generation therapeutics.

Quality Assurance and Storage

Quality control is paramount in our production facility. Each batch undergoes rigorous analytical testing including HPLC, NMR, and moisture analysis to verify compliance with specifications. We provide a comprehensive Certificate of Analysis (COA) with every shipment, ensuring transparency and traceability for our partners.

For optimal stability, store this product in a tightly closed container within a cool, dry, and well-ventilated area. Protect from moisture and incompatible substances to maintain integrity. Our packaging options include 25 kg drums or customized solutions based on specific logistical requirements, ensuring safe transport globally.

Why Choose Our Supply

  • Consistent high purity levels suitable for sensitive synthetic reactions
  • Scalable manufacturing capacity to meet bulk demand
  • Competitive pricing structures for long-term partnerships
  • Technical support available for application guidance
  • Global shipping capabilities with secure packaging