2-Chloro-5-fluoro-3-nitropyridine
- CAS No.136888-21-6
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High-purity 2-Chloro-5-fluoro-3-nitropyridine (CAS 136888-21-6), a versatile pyridine-based intermediate for advanced organic synthesis in pharmaceutical and agrochemical R&D.
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Product Overview
2-Chloro-5-fluoro-3-nitropyridine is a high-value heterocyclic building block widely employed in the synthesis of complex active pharmaceutical ingredients (APIs) and specialty agrochemical compounds. This fluorinated nitropyridine derivative features a unique combination of electron-withdrawing substituents that enhance its reactivity in nucleophilic aromatic substitution and cross-coupling reactions, making it an indispensable intermediate in modern medicinal chemistry workflows.
Specifications
| Molecular Formula | C5H2ClFN2O2 |
|---|---|
| Molecular Weight | 176.533 g/mol |
| CAS Number | 136888-21-6 |
| Appearance | Yellow crystalline powder |
| Assay | ≥98.0% |
| Melting Point | 48.0 to 52.0 °C |
| Boiling Point | 246.2 ± 35.0 °C at 760 mmHg |
| Density | 1.6 ± 0.1 g/cm³ |
| Flash Point | 102.7 ± 25.9 °C |
| Vapour Pressure | 0.0 ± 0.5 mmHg at 25 °C |
| Refractive Index | 1.560 |
Industrial Applications
As a specialized pyridine core scaffold, 2-Chloro-5-fluoro-3-nitropyridine serves as a critical precursor in multi-step synthetic routes targeting novel therapeutic agents and crop protection molecules. Its strategic placement of chlorine, fluorine, and nitro functional groups enables sequential functionalization under controlled conditions, facilitating the construction of structurally diverse compound libraries for drug discovery programs.
- Ideal for Suzuki, Buchwald-Hartwig, and other palladium-catalyzed transformations
- Enables regioselective derivatization due to differential reactivity of halogen sites
- Supports development of kinase inhibitors, antimicrobial agents, and herbicidal leads
Stored in a cool, well-ventilated area away from incompatible materials, this intermediate is typically supplied in 25 kg drums or customized packaging to meet global regulatory and logistical requirements.
