2-Chloro-5-fluorobenzaldehyde
- CAS No.84194-30-9
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High-purity 2-Chloro-5-fluorobenzaldehyde (CAS 84194-30-9), a key halogenated aromatic aldehyde intermediate for advanced organic synthesis in pharmaceutical and agrochemical R&D.
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Product Overview
2-Chloro-5-fluorobenzaldehyde is a high-value halogenated aromatic aldehyde widely employed as a critical building block in the synthesis of complex organic molecules. With its dual halogen substitution pattern—chlorine at the ortho position and fluorine at the meta position relative to the aldehyde group—it offers unique reactivity and regioselectivity for cross-coupling, nucleophilic addition, and condensation reactions. This compound is essential in the development of active pharmaceutical ingredients (APIs), crop protection agents, and specialty functional materials.
Specifications
| Molecular Formula | C₇H₄ClFO |
|---|---|
| Molecular Weight | 158.56 g/mol |
| CAS Number | 84194-30-9 |
| Appearance | Off-white crystalline solid |
| Purity (GC) | ≥99.0% |
| Melting Point | 60–63°C |
| Boiling Point | 204.5°C |
| Density | 1.352 g/cm³ |
| Refractive Index | 1.559 |
| Flash Point | 80.9°C |
Industrial Applications
As a versatile synthetic intermediate, 2-Chloro-5-fluorobenzaldehyde serves multiple roles across the fine chemical industry:
- Core scaffold in multi-step syntheses of heterocyclic compounds used in medicinal chemistry.
- Precursor for fluorinated analogs in structure-activity relationship (SAR) studies.
- Building block for liquid crystals, OLED materials, and other electronic-grade organics.
- Intermediate in the production of selective herbicides and fungicides.
Its defined halogen placement enables precise functionalization under mild conditions, making it ideal for late-stage diversification strategies in drug discovery pipelines.
Handling and Storage
Store in a cool, dry, and well-ventilated area away from heat sources and incompatible materials. Keep container tightly closed to prevent moisture absorption and degradation. Standard industrial hygiene practices are recommended during handling.
