2-Chloro-5-fluoropyridine
- CAS No.31301-51-6
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High-purity 2-Chloro-5-fluoropyridine (CAS 31301-51-6) is a versatile halogenated pyridine derivative widely used as a key building block in pharmaceutical and agrochemical synthesis.
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Product Overview
2-Chloro-5-fluoropyridine is a halogen-substituted heterocyclic compound belonging to the pyridine family. With both chlorine and fluorine atoms strategically positioned on the aromatic ring, it serves as a highly valuable synthon in modern organic synthesis. This molecule exhibits excellent reactivity in cross-coupling reactions, nucleophilic substitutions, and metal-halogen exchange processes, making it indispensable for constructing complex molecular architectures in medicinal chemistry and crop protection research.
Specifications
| Molecular Formula | C5H3ClFN |
|---|---|
| Molecular Weight | 131.54 g/mol |
| Density | 1.297 g/cm³ |
| Boiling Point | 74°C |
| Flash Point | 108°C |
| Refractive Index | 1.503 |
| Assay (GC) | ≥98.0% (Typical: 99.5%) |
| Moisture | ≤0.5% (Typical: 0.08%) |
| Appearance | Colourless to yellow to tan liquid or solid |
Industrial Applications
As a critical intermediate in fine chemical manufacturing, 2-Chloro-5-fluoropyridine is primarily employed in the synthesis of active pharmaceutical ingredients (APIs), veterinary medicines, and advanced agrochemicals. Its dual halogen functionality enables sequential functionalization, allowing chemists to introduce diverse substituents with high regioselectivity. The compound is particularly useful in Suzuki, Buchwald-Hartwig, and other palladium-catalyzed transformations.
- Ideal for multi-step synthetic routes requiring orthogonal reactivity
- Enables efficient construction of fluorinated bioactive molecules
- Compatible with standard handling protocols for moisture-sensitive intermediates
Stored in a cool, well-ventilated area away from heat and ignition sources, this product is typically supplied in 200 kg drums or customized packaging to meet client specifications. Rigorous quality control ensures batch-to-batch consistency and compliance with international regulatory standards.
