2-Deoxy-2,2-difluoro-D-ribofuranose-3,5-dibenzoate
- CAS No.143157-22-6
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High-purity 2-Deoxy-2,2-difluoro-D-ribofuranose-3,5-dibenzoate (CAS 143157-22-6) designed for pharmaceutical synthesis. Reliable supply for Gemcitabine production with strict quality control.
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Product Overview
2-Deoxy-2,2-difluoro-D-ribofuranose-3,5-dibenzoate is a specialized fluorinated sugar derivative serving as a critical building block in modern medicinal chemistry. Identified by CAS number 143157-22-6, this compound features a unique difluoro substitution pattern on the ribofuranose ring, which significantly enhances metabolic stability and bioavailability in downstream nucleoside analogs. Our facility produces this intermediate under rigorous quality management systems to ensure consistency for large-scale pharmaceutical manufacturing.
The introduction of fluorine atoms at the 2-position of the ribose moiety is a strategic modification widely utilized in the development of anticancer agents. This specific dibenzoate protected form offers superior handling properties and reactivity profiles, making it an ideal precursor for the synthesis of complex nucleoside therapeutics. We prioritize the delivery of materials that meet exacting standards for purity and stereochemical integrity.
Key Specifications
| Parameter | Value |
|---|---|
| Chemical Name | 2-Deoxy-2,2-difluoro-D-ribofuranose-3,5-dibenzoate |
| CAS Number | 143157-22-6 |
| Molecular Formula | C19H16F2O6 |
| Molecular Weight | 378.32 g/mol |
| Purity | ≥99.0% |
| Appearance | Off-white to pale yellow low melting solid or liquid |
| Density | 1.41 g/cm3 |
| Boiling Point | 495.925°C |
| Flash Point | 253.726°C |
Industrial Applications
The primary application of this compound lies in the synthesis of Gemcitabine, a potent chemotherapy medication used to treat various types of cancer including pancreatic, lung, and breast cancer. As a key intermediate, it provides the essential fluorinated ribose scaffold required for the biological activity of the final active pharmaceutical ingredient (API). The high purity levels we maintain are crucial for minimizing impurities in the final drug product, ensuring patient safety and regulatory compliance.
Beyond Gemcitabine, this difluororibose derivative is valuable for research and development into next-generation nucleoside analogs. Medicinal chemists utilize this building block to explore structure-activity relationships in antiviral and antineoplastic agents. The benzoyl protecting groups facilitate selective deprotection strategies during multi-step synthesis routes, allowing for precise construction of complex molecular architectures.
Quality Assurance and Storage
We understand that the reliability of your synthesis process depends on the quality of your starting materials. Each batch of 2-Deoxy-2,2-difluoro-D-ribofuranose-3,5-dibenzoate undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to verify identity and purity. A Certificate of Analysis (COA) is provided with every shipment to document compliance with specifications.
- Packaged in 25 kg drums or customized according to client requirements.
- Stored in a cool, ventilated environment to maintain stability.
- Protected from moisture and direct sunlight during transit.
- Global shipping capabilities with secure logistics partners.
For technical inquiries, bulk pricing, or custom synthesis requests, our team of experts is available to support your pharmaceutical development projects. We are committed to being a trusted partner in the global supply chain for advanced chemical intermediates.
