2'-Deoxy-2'-fluorouridine
- CAS No.784-71-4
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High-purity 2'-Deoxy-2'-fluorouridine (CAS 784-71-4) designed for advanced oligonucleotide synthesis and pharmaceutical research applications.
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Product Overview
2'-Deoxy-2'-fluorouridine is a specialized fluorinated nucleoside analog that plays a critical role in modern medicinal chemistry and biopharmaceutical development. As a modified building block, this compound features a fluorine substitution at the 2'-position of the ribose sugar moiety, which significantly enhances metabolic stability and binding affinity when incorporated into oligonucleotide sequences. Our facility produces this high-value intermediate under strict quality control standards to support the synthesis of therapeutic antisense oligonucleotides and siRNA candidates.
The introduction of fluorine atoms into nucleoside structures is a proven strategy to improve nuclease resistance and pharmacokinetic profiles. This makes 2'-Deoxy-2'-fluorouridine an essential component for researchers developing next-generation treatments for oncology and genetic disorders. We supply this material with consistent batch-to-batch reproducibility, ensuring reliable performance in downstream synthesis processes.
Key Specifications
We adhere to rigorous analytical protocols to guarantee the purity and integrity of every shipment. The following table outlines the standard specifications and typical test results for our commercial grade material.
| Parameter | Specification | Typical Result |
|---|---|---|
| Appearance | White or almost white crystalline powder | Conforms |
| CAS Number | 784-71-4 | 784-71-4 |
| Molecular Formula | C9H11FN2O5 | Conforms |
| Molecular Weight | 246.19 g/mol | 246.19 |
| Purity (HPLC) | ≥98.0% | 98.9% |
| Loss on Drying | ≤1.0% | 0.1% |
| Heavy Metals | ≤20 ppm | Conforms |
Industrial Applications
This fluorinated nucleoside is primarily utilized as a key intermediate in the solid-phase synthesis of modified oligonucleotides. Its primary applications include:
- Development of therapeutic oligonucleotides for oncology indications such as prostate and breast cancer.
- Construction of antisense drugs with enhanced stability against enzymatic degradation.
- Research into gene silencing mechanisms and RNA interference technologies.
- Use as a reference standard in analytical method validation for nucleoside analogs.
By integrating this building block into drug candidates, pharmaceutical companies can achieve improved bioavailability and target specificity. Our production process is optimized to minimize impurities that could interfere with coupling reactions during oligonucleotide assembly.
Quality Assurance and Storage
Quality is paramount in the supply of pharmaceutical intermediates. Each batch undergoes comprehensive testing using high-performance liquid chromatography (HPLC) and other validated methods. We provide a Certificate of Analysis (COA) with every order, detailing all critical quality attributes. Our manufacturing facility follows Good Manufacturing Practice (GMP) guidelines to ensure safety and consistency.
For optimal stability, 2'-Deoxy-2'-fluorouridine should be stored in a cool, ventilated environment away from direct sunlight and moisture. The standard packaging is 25 kg per drum, though we offer flexible packaging solutions to meet specific customer logistics requirements. Proper handling ensures the material maintains its specified purity throughout its shelf life.
