2'-Deoxyuridine 5'-Monophosphate Disodium Salt

Product Overview

2'-Deoxyuridine 5'-monophosphate disodium salt (dUMP disodium salt) is a critical nucleotide intermediate in biochemical and pharmaceutical research. With the CAS number 42155-08-8 and molecular formula C9H11N2Na2O8P, this compound serves as the natural substrate for thymidylate synthase (TS; EC 2.1.1.45), an enzyme essential for the de novo synthesis of deoxythymidine monophosphate (dTMP)—a fundamental building block for DNA replication and repair.

Specifications

Industrial Applications

This high-purity nucleotide salt is primarily employed as a reference standard in enzymatic assays and structure-activity relationship (SAR) studies involving dUMP analogues. Its role in thymidylate metabolism makes it invaluable for investigating antifolate and antimetabolite drug mechanisms, particularly in oncology-focused research programs exploring novel chemotherapeutic strategies. As a non-terminal building block, it supports advanced organic synthesis pathways rather than direct formulation into final consumer products.

• Serves as the native substrate for thymidylate synthase in dTMP biosynthesis
• Used as a benchmark compound in the development of nucleotide-based enzyme inhibitors
• Enables high-fidelity enzymatic and kinetic studies in molecular pharmacology
• Manufactured under stringent quality controls for reproducibility in research settings

Stored in a cool, well-ventilated environment and typically packaged in 25 kg drums (custom packaging available upon request), this intermediate meets the rigorous demands of global biopharmaceutical R&D and fine chemical manufacturing.