2-(Difluoromethoxy)aniline
- CAS No.22236-04-0
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High-purity 2-(Difluoromethoxy)aniline (CAS 22236-04-0), a key fluorinated intermediate for advanced organic synthesis in pharmaceutical and agrochemical R&D.
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Product Overview
2-(Difluoromethoxy)aniline is a high-value fluorinated aromatic amine widely employed as a critical building block in modern organic synthesis. With its unique difluoromethoxy substituent adjacent to the amino group, this compound offers enhanced metabolic stability and lipophilicity—properties highly sought after in the design of bioactive molecules. It serves primarily as an intermediate in the development of complex pharmaceutical APIs and specialty agrochemicals, where precise molecular architecture and functional group compatibility are essential.
Specifications
| Molecular Formula | C7H7F2NO |
|---|---|
| Molecular Weight | 159.133 g/mol |
| Density | 1.3 ± 0.1 g/cm³ |
| Boiling Point | 209.8 ± 30.0 °C at 760 mmHg |
| Flash Point | 80.7 ± 24.6 °C |
| Vapour Pressure | 0.2 ± 0.4 mmHg at 25°C |
| Refractive Index | 1.502 |
| Appearance | Colorless transparent liquid |
| Assay | ≥98.0% |
Industrial Applications
As a specialized fluorochemical intermediate, 2-(Difluoromethoxy)aniline is integral to multi-step synthetic routes requiring regioselective functionalization. Its applications include:
- Serving as a precursor in the synthesis of heterocyclic scaffolds for neurological therapeutics and anti-infective agents.
- Enabling the construction of novel agrochemical actives with improved environmental persistence profiles.
- Facilitating structure-activity relationship (SAR) studies in medicinal chemistry through late-stage diversification.
Due to its reactivity and sensitivity, it must be handled under inert atmosphere and stored in a cool, well-ventilated area away from oxidizing agents. Standard packaging is 200 kg per drum, with custom configurations available upon request to meet global regulatory and logistical requirements.
