2-Fluoro-3-Methoxyphenylboronic Acid
- CAS No.352303-67-4
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High-purity 2-Fluoro-3-Methoxyphenylboronic Acid (CAS 352303-67-4) designed for pharmaceutical synthesis, specifically as a key intermediate for Elagolix production with ≥99.0% assay.
Request Bulk PricingProduct Technical Details
Product Overview
2-Fluoro-3-Methoxyphenylboronic Acid is a highly specialized organoboron compound extensively utilized in modern medicinal chemistry and organic synthesis. As a critical building block, this fluorinated boronic acid derivative facilitates efficient carbon-carbon bond formation, particularly through palladium-catalyzed cross-coupling reactions. Our manufacturing process ensures exceptional chemical stability and reactivity, making it an indispensable reagent for complex pharmaceutical architectures.
The presence of both fluorine and methoxy substituents on the phenyl ring enhances the metabolic stability and bioavailability of downstream drug candidates. This specific structural configuration is vital for the synthesis of advanced therapeutic agents, including key intermediates for Elagolix. We adhere to strict quality control protocols to deliver material that meets rigorous international standards for pharmaceutical development.
Technical Specifications
| Parameter | Value |
|---|---|
| Product Name | 2-Fluoro-3-Methoxyphenylboronic Acid |
| CAS Number | 352303-67-4 |
| Molecular Formula | C7H8BFO3 |
| Molecular Weight | 169.95 g/mol |
| Appearance | White to off-white powder |
| Assay (Purity) | ≥99.0% |
| Water Content | ≤0.50% |
| Melting Point | 117-122 °C |
| Density | 1.26 g/cm³ |
| Boiling Point | 326.8 °C at 760 mmHg |
Industrial Applications
This boronic acid derivative serves as a versatile synthon in the construction of biaryl structures found in numerous active pharmaceutical ingredients. Its primary application lies in Suzuki-Miyaura coupling reactions, where it acts as a nucleophilic partner to introduce substituted phenyl groups into complex molecules. The high purity level ensures minimal side reactions and improved yields during scale-up processes.
- Pharmaceutical Intermediate: Essential for the synthesis of Elagolix and related GnRH antagonists.
- Medicinal Chemistry: Used in lead optimization and structure-activity relationship (SAR) studies.
- Agrochemical Synthesis: Applicable in the development of novel pesticide formulations requiring fluorinated aromatics.
- Material Science: Potential use in the creation of specialized organic polymers and electronic materials.
Quality Assurance and Storage
We maintain a robust quality management system to guarantee consistency across every batch. Each shipment is accompanied by a comprehensive Certificate of Analysis (COA) detailing physical and chemical properties. To preserve integrity, the product should be stored in a cool, dry, and well-ventilated area away from incompatible materials. Containers must remain tightly closed to prevent moisture absorption, which can affect boronic acid stability. We offer flexible packaging options, including 25kg drums, tailored to meet specific logistical requirements for global distribution.
