Intermediates

2-Fluoro-3-methyl-5-nitropyridine

  • CAS No.19346-46-4
  • GradeIndustrial / Pharmaceutical
  • Availability● In Stock

High-purity 2-Fluoro-3-methyl-5-nitropyridine (CAS 19346-46-4) designed for advanced pharmaceutical intermediate synthesis and organic chemistry applications.

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Product Technical Details

Product Overview

2-Fluoro-3-methyl-5-nitropyridine is a specialized fluorinated heterocyclic compound that serves as a vital building block in modern organic synthesis. As a key intermediate, this chemical facilitates the construction of complex molecular architectures required in the development of advanced pharmaceutical agents and agrochemical solutions. The presence of the fluorine atom at the second position enhances metabolic stability and bioavailability in downstream products, making it a preferred choice for medicinal chemists.

Our manufacturing process ensures consistent quality and high purity levels, adhering to strict international standards. This compound is characterized by its stable nitro group and reactive fluoro substituent, which allows for versatile nucleophilic substitution reactions. Whether utilized in cross-coupling protocols or heterocyclic ring modifications, this material provides reliable performance for research and industrial scale production.

Technical Specifications

ParameterValue
Chemical Name2-Fluoro-3-methyl-5-nitropyridine
CAS Number19346-46-4
Molecular FormulaC6H5FN2O2
Molecular Weight156.12 g/mol
AppearanceWhite Crystalline Powder
Purity≥99.0%
Density1.357 g/cm3
Boiling Point265.7°C at 760mmHg
Flash Point114.5°C
Refractive Index1.533

Industrial Applications

This fluorinated pyridine derivative is primarily employed in the synthesis of pharmaceutical intermediates. Its unique structural properties enable chemists to introduce specific functional groups into drug candidates with high precision. Common applications include the development of kinase inhibitors, antibacterial agents, and other therapeutic molecules where fluorine substitution is critical for optimizing pharmacokinetic profiles.

Additionally, this compound serves as a valuable reagent in academic and industrial research laboratories focused on heterocyclic chemistry. The high purity specification ensures minimal side reactions during synthesis, leading to improved yields and reduced purification costs. Our supply chain supports both small-scale research batches and large-scale commercial manufacturing requirements.

Quality Assurance and Storage

Quality control is paramount in our production facility. Each batch of 2-Fluoro-3-methyl-5-nitropyridine undergoes rigorous testing using advanced analytical techniques such as HPLC and NMR to verify identity and purity. A Certificate of Analysis (COA) is provided with every shipment to guarantee compliance with specified parameters.

For optimal stability, the product should be stored in a tightly closed container within a cool, dry environment. Proper handling procedures must be followed to maintain integrity during transportation and storage. We recommend keeping the material away from incompatible substances and sources of ignition due to its chemical nature. Our packaging options include 25 kg drums, ensuring safe and efficient delivery to global destinations.