2-Fluoro-3-(trifluoromethyl)pyridine
- CAS No.65753-52-8
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High-purity 2-Fluoro-3-(trifluoromethyl)pyridine (CAS 65753-52-8) designed for advanced organic synthesis. Reliable supply with ≥98.0% assay for pharmaceutical and agrochemical manufacturing.
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Product Overview
2-Fluoro-3-(trifluoromethyl)pyridine represents a critical advancement in fluorinated heterocyclic chemistry, serving as a versatile building block for modern pharmaceutical and agrochemical development. This colorless transparent liquid is engineered to facilitate the introduction of both fluoro and trifluoromethyl groups into complex molecular architectures, enhancing metabolic stability and bioavailability in final drug candidates. Our manufacturing process ensures consistent high purity, making it an ideal choice for researchers and industrial-scale synthesis operations requiring reliable raw materials.
The unique substitution pattern on the pyridine ring allows for selective nucleophilic aromatic substitution reactions, providing chemists with precise control over downstream derivatization. As a key intermediate, this compound supports the creation of novel therapeutic agents targeting various disease states, alongside high-performance agricultural solutions. We prioritize quality assurance at every production stage, adhering to strict international standards to deliver materials that meet the rigorous demands of global supply chains.
Technical Specifications
| Parameter | Value |
|---|---|
| CAS Number | 65753-52-8 |
| Molecular Formula | C6H3F4N |
| Molecular Weight | 165.09 g/mol |
| Appearance | Colorless transparent liquid |
| Assay (Purity) | ≥98.0% |
| Density | 1.371 g/cm3 |
| Boiling Point | 149.3°C at 760 mmHg |
| Flash Point | 44.1°C |
| Refractive Index | 1.523 |
Industrial Applications
This fluorinated pyridine derivative is extensively utilized in the synthesis of advanced organic compounds. Its primary application lies within the pharmaceutical sector, where it serves as a precursor for kinase inhibitors, receptor modulators, and other small molecule drugs. The presence of the trifluoromethyl group significantly improves the lipophilicity and membrane permeability of resulting molecules, which is crucial for oral bioavailability.
- Pharmaceutical Intermediate: Essential for constructing heterocyclic cores in new drug entities.
- Agrochemical Synthesis: Used in developing herbicides and pesticides with enhanced environmental profiles.
- Material Science: Applied in the creation of specialized polymers and electronic materials requiring fluorinated components.
- Research and Development: A standard reagent for academic and industrial laboratories focusing on medicinal chemistry.
Quality Assurance and Logistics
We understand the importance of supply chain reliability in the chemical industry. Each batch of 2-Fluoro-3-(trifluoromethyl)pyridine undergoes comprehensive analytical testing, including GC, HPLC, and NMR spectroscopy, to verify identity and purity. A Certificate of Analysis (COA) is provided with every shipment to ensure full transparency and compliance with your internal quality protocols. Our facility is equipped to handle bulk orders efficiently, offering flexible packaging solutions such as 200 kg drums or customized containers based on specific client requirements.
Proper storage is vital to maintain product integrity. We recommend storing this material in a cool, ventilated area away from direct sunlight and incompatible substances. Our logistics partners are experienced in handling hazardous chemicals, ensuring safe and timely delivery to destinations worldwide. By choosing our company as your manufacturer, you gain access to technical support, competitive bulk pricing, and a commitment to long-term partnership grounded in quality and trust.
