2-Fluoro-4-iodobenzonitrile
- CAS No.137553-42-5
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High-purity 2-Fluoro-4-iodobenzonitrile (CAS 137553-42-5) designed for advanced organic synthesis. Reliable supply with strict quality control for pharmaceutical intermediates.
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Product Overview
2-Fluoro-4-iodobenzonitrile is a specialized halogenated aromatic compound widely recognized for its versatility in modern organic synthesis and medicinal chemistry. As a key building block, this compound features both fluorine and iodine substituents on the benzene ring, enabling diverse chemical transformations. The presence of the nitrile group further enhances its reactivity, making it an invaluable precursor for the development of complex pharmaceutical agents and agrochemicals.
Our manufacturing process ensures exceptional consistency and purity, catering to the rigorous demands of research laboratories and industrial production facilities. This intermediate is particularly valued for its stability and predictable reactivity profiles in cross-coupling reactions.
Technical Specifications
| Parameter | Value |
|---|---|
| Chemical Name | 2-Fluoro-4-iodobenzonitrile |
| CAS Number | 137553-42-5 |
| Molecular Formula | C7H3FIN |
| Molecular Weight | 247.008 g/mol |
| Appearance | Off-white to light yellow powder |
| Assay | ≥98.0% |
| Melting Point | 103.7-104.6 °C |
| Boiling Point | 264.0±25.0 °C at 760 mmHg |
| Density | 2.0±0.1 g/cm3 |
| Loss on Drying | ≤0.3% |
Industrial Applications
This compound serves as a critical intermediate in the synthesis of various bioactive molecules. The iodine substituent allows for efficient palladium-catalyzed cross-coupling reactions, such as Suzuki, Heck, and Sonogashira couplings. Meanwhile, the fluorine atom can significantly influence the metabolic stability and lipophilicity of the final drug candidate, a crucial factor in pharmaceutical design.
- Pharmaceutical Intermediate: Used in the synthesis of kinase inhibitors and receptor modulators.
- Agrochemical Synthesis: Acts as a precursor for novel herbicides and pesticides.
- Material Science: Employed in the development of organic electronic materials and polymers.
- Research and Development: Essential for medicinal chemistry libraries and structure-activity relationship studies.
Quality Assurance and Storage
We adhere to strict quality management systems to guarantee the integrity of every batch. Each shipment is accompanied by a comprehensive Certificate of Analysis (COA) verifying all physical and chemical parameters. Our facility utilizes advanced analytical instrumentation, including HPLC and NMR, to confirm identity and purity levels.
For optimal preservation, 2-Fluoro-4-iodobenzonitrile should be stored in a cool, ventilated place away from direct sunlight and moisture. The standard packaging is 25 kg per drum, though we offer flexible customization to meet specific logistical requirements. Proper handling procedures should be followed to maintain safety and product quality during transport and usage.
