2-Fluoro-4-Iodopyridine
- CAS No.22282-70-8
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High-purity 2-Fluoro-4-Iodopyridine designed for advanced pharmaceutical intermediate synthesis and heterocyclic chemistry applications.
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Product Overview
2-Fluoro-4-Iodopyridine is a highly specialized heterocyclic building block extensively utilized in modern medicinal chemistry and organic synthesis. As a halogenated pyridine derivative, this compound combines the unique electronic properties of fluorine with the reactive versatility of iodine, making it an indispensable precursor for the development of complex pharmaceutical agents. Our manufacturing process ensures exceptional batch-to-batch consistency, catering to the rigorous demands of research laboratories and large-scale production facilities alike.
The strategic placement of the fluoro and iodo substituents on the pyridine ring facilitates diverse chemical transformations. This molecule serves as a critical intermediate in the synthesis of kinase inhibitors, antiviral agents, and other bioactive compounds where precise structural modification is required. By sourcing this material from a certified global manufacturer, clients gain access to premium quality chemicals that adhere to international safety and purity standards.
Key Specifications
| Parameter | Value |
|---|---|
| CAS Number | 22282-70-8 |
| Molecular Formula | C5H3FIN |
| Molecular Weight | 222.99 g/mol |
| Purity | ≥98.0% |
| Appearance | Shallow color solid |
| Melting Point | 57 °C |
| Boiling Point | 223 °C at 760 mmHg |
| Density | 2.046 g/cm3 |
| Refractive Index | 1.599 |
| Flash Point | 88.6 °C |
Industrial Applications
In the realm of pharmaceutical development, 2-Fluoro-4-Iodopyridine is primarily employed as a key synthon for cross-coupling reactions. The carbon-iodine bond is particularly susceptible to palladium-catalyzed processes such as Suzuki-Miyaura, Heck, and Sonogashira couplings. This reactivity allows chemists to introduce various functional groups at the fourth position of the pyridine ring while retaining the fluorine atom, which often enhances the metabolic stability and bioavailability of the final drug candidate.
Furthermore, this compound is vital in the construction of fused heterocyclic systems found in numerous therapeutic classes. Its high purity level ensures minimal side reactions during synthesis, thereby improving overall yield and reducing downstream purification costs. Whether used in early-stage drug discovery or process chemistry for active pharmaceutical ingredients (APIs), this intermediate provides a reliable foundation for innovative chemical solutions.
Quality Assurance and Storage
We maintain strict quality control protocols throughout the production lifecycle. Each batch undergoes comprehensive analytical testing, including HPLC and NMR spectroscopy, to verify identity and purity. A Certificate of Analysis (COA) is provided with every shipment to guarantee compliance with specified parameters. Our commitment to quality ensures that researchers can proceed with their projects without concern for material variability.
- Packaged in secure 25 KGS drums to maintain integrity during transit.
- Store in a tightly closed container in a cool, dry, and well-ventilated area.
- Protect from moisture and light to prevent degradation of the iodo substituent.
- Handle with appropriate personal protective equipment in accordance with safety data sheets.
- Available for global shipping with documented supply chain transparency.
For inquiries regarding bulk pricing, custom synthesis capabilities, or technical support, please contact our sales team. We are dedicated to supporting your chemical procurement needs with reliability and expertise.
