2-Fluoro-4-methyl-3-nitropyridine

Product Overview

2-Fluoro-4-methyl-3-nitropyridine (CAS 19346-43-1) is a sophisticated fluorinated heterocyclic compound designed for advanced organic synthesis. As a critical building block in the pharmaceutical industry, this substance offers unique reactivity profiles that facilitate the construction of complex molecular architectures. Our facility produces this intermediate under strict quality control standards to ensure consistency and reliability for downstream applications. The material is supplied as a white crystalline powder, meeting high purity specifications required for sensitive chemical transformations.

The presence of the fluorine atom at the second position of the pyridine ring significantly enhances the metabolic stability of resulting drug candidates. Furthermore, the nitro group at the third position provides a versatile handle for chemical transformation, including reduction to amines or participation in cyclization reactions. This dual functionality makes it an invaluable asset for medicinal chemists developing new therapeutic agents targeting various disease pathways.

Technical Specifications

Physical and Chemical Properties

Understanding the physicochemical characteristics is essential for safe handling and process optimization. The compound exhibits a density of 1.358 g/cm3 and a boiling point of approximately 263.974ºC at 760 mmHg. The flash point is recorded at 113.448ºC, indicating specific safety protocols during storage and transport. The refractive index of 1.533 further confirms the high quality and identity of the material. These properties are critical for engineers designing reaction vessels and separation processes.

Industrial Applications

This chemical is predominantly utilized as a pharmaceutical intermediate. It serves as a precursor in the synthesis of various active pharmaceutical ingredients (APIs), particularly those targeting neurological and oncological pathways. The fluorinated pyridine scaffold is a common motif in kinase inhibitors and other small molecule drugs. Manufacturers rely on high-purity batches to minimize impurities in the final drug product, ensuring regulatory compliance and patient safety. Our product supports scale-up from laboratory research to commercial manufacturing.

Quality Assurance and Storage

We implement a comprehensive quality assurance program that includes rigorous testing via HPLC and NMR spectroscopy. Each batch is accompanied by a Certificate of Analysis (COA) to verify compliance with specified parameters. For storage, the product must be kept in a tightly closed container within a cool, dry environment to prevent degradation. Proper handling ensures the longevity and efficacy of the material for your synthesis projects. Packaging is designed to maintain integrity during transit, typically involving 25 KGS per drum. We also accommodate custom packaging requests based on specific logistical requirements. Our supply chain is optimized to deliver materials promptly while maintaining specific environmental conditions if necessary. Choosing the right supplier for chemical intermediates is crucial for maintaining production schedules. Our team provides technical support to assist with integration into your existing synthesis routes. We understand the complexities of scale-up and offer consistent quality to prevent batch-to-batch variability. Trust our expertise for your fluorinated building block needs.