Intermediates

2-Fluoro-4-methyl-5-nitropyridine

  • CAS No.19346-47-5
  • GradeIndustrial / Pharmaceutical
  • Availability● In Stock

High-purity 2-Fluoro-4-methyl-5-nitropyridine (CAS 19346-47-5) designed for pharmaceutical synthesis. Available in bulk with certified quality assurance.

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Product Technical Details

Product Overview

2-Fluoro-4-methyl-5-nitropyridine represents a critical fluorinated heterocyclic building block within the realm of advanced organic synthesis. As a specialized pyridine derivative, this compound plays an indispensable role in the construction of complex molecular architectures required for modern pharmaceutical and agrochemical development. The strategic incorporation of fluorine atoms into organic structures is known to significantly enhance metabolic stability, bioavailability, and binding affinity in drug candidates, making this intermediate highly valuable for medicinal chemistry programs.

Our facility produces this chemical using state-of-the-art fluorination and nitration techniques to ensure consistent quality and high yield. We understand the stringent requirements of downstream synthesis, which is why our manufacturing process focuses on minimizing impurities and maximizing regioselectivity. This product serves as a versatile precursor for nucleophilic aromatic substitution reactions, allowing chemists to introduce various functional groups at the 2-position of the pyridine ring efficiently.

Technical Specifications

We adhere to rigorous quality control standards to guarantee that every batch meets the specified physical and chemical properties. The following table outlines the key parameters verified during our internal quality assurance protocols.

ParameterSpecification
Chemical Name2-Fluoro-4-methyl-5-nitropyridine
CAS Number19346-47-5
Molecular FormulaC6H5FN2O2
Molecular Weight156.12 g/mol
AppearanceColorless liquid
Purity≥99.0%
Density1.357 g/cm3
Boiling Point254.7°C at 760 mmHg
Flash Point107.8°C
Refractive Index1.533

Industrial Applications

This fluorinated pyridine intermediate is primarily utilized in the synthesis of active pharmaceutical ingredients (APIs) and fine chemicals. Its unique substitution pattern allows for selective functionalization, making it a preferred choice for developing kinase inhibitors, antiviral agents, and other therapeutic compounds. Beyond pharmaceuticals, it finds application in the agrochemical sector for creating novel pesticides and herbicides where enhanced environmental stability is required.

  • Pharmaceutical intermediate for drug discovery
  • Precursor for fluorinated heterocycles
  • Building block for agrochemical formulations
  • Reagent for organic synthesis research

Quality Assurance and Safety

Quality is the cornerstone of our operation. Each production batch undergoes comprehensive analysis using HPLC and NMR spectroscopy to confirm identity and purity. We provide a Certificate of Analysis (COA) with every shipment to ensure transparency and compliance with your internal standards. Regarding safety, this compound should be handled in a well-ventilated area with appropriate personal protective equipment. It must be stored in tightly closed containers in a cool, dry environment away from incompatible materials such as strong oxidizing agents. Our packaging options include 25 kg drums, customized to meet global shipping regulations and ensure product integrity during transit.