2-Fluoro-4-methylaniline
- CAS No.452-80-2
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High purity 2-Fluoro-4-methylaniline (CAS 452-80-2) supplied for pharmaceutical synthesis. Reliable global manufacturer with strict quality control and comprehensive documentation.
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Product Overview
2-Fluoro-4-methylaniline, also known commercially as 4-Amino-3-fluorotoluene or 2-Fluoro-p-toluidine, is a specialized fluorinated organic compound serving as a critical building block in modern medicinal chemistry. With the CAS registry number 452-80-2, this substance features a unique molecular structure (C7H8FN) that combines the reactivity of an aniline derivative with the metabolic stability imparted by the fluorine substituent. Our facility produces this intermediate under stringent quality management systems to ensure consistency for downstream synthetic applications.
The introduction of fluorine into aromatic systems is a pivotal strategy in drug design, often enhancing bioavailability and binding affinity. As a trusted global manufacturer, we provide this material with high chemical purity, suitable for complex organic synthesis routes required in the development of advanced pharmaceutical agents and agrochemical products.
Technical Specifications
We adhere to rigorous analytical standards to guarantee the performance of our chemicals. Each batch is accompanied by a Certificate of Analysis (COA) verifying compliance with the following parameters:
| Parameter | Specification |
|---|---|
| Product Name | 2-Fluoro-4-methylaniline |
| CAS Number | 452-80-2 |
| Molecular Formula | C7H8FN |
| Molecular Weight | 125.14 g/mol |
| Appearance | Light yellow transparent liquid |
| Purity | ≥98.0% |
| Water Content | ≤0.5% |
| Density | 1.108 g/mL at 25 °C |
| Boiling Point | 70-71 °C at 7 mm Hg |
| Melting Point | 3 °C |
| Refractive Index | n20/D 1.533 |
Industrial Applications
This fluorinated aniline derivative is primarily utilized as a key intermediate in the synthesis of various active pharmaceutical ingredients (APIs). Its specific substitution pattern allows for selective functionalization, making it invaluable for constructing complex molecular architectures. Key application areas include:
- Pharmaceutical Intermediate: Used in the production of kinase inhibitors and other targeted therapies.
- Agrochemical Synthesis: Serves as a precursor for specialized herbicides and pesticides.
- Organic Research: Employed in laboratory settings for developing new fluorination methodologies.
- Material Science: Utilized in the creation of specialized polymers with enhanced thermal properties.
Quality Assurance and Safety
Safety and compliance are paramount in our manufacturing process. This product is classified under Transport Hazard Class 6.1 (Toxic Liquid, Organic, N.O.S.) with UN Number UN2810. We ensure all packaging meets international shipping regulations for hazardous materials. The substance is packed in 25kg plastic drums or plastic-coated iron drums to maintain integrity during transit.
For optimal storage, keep the container tightly closed in a cool, dry, and well-ventilated place away from incompatible substances. Our quality control team performs multiple checks throughout the production cycle, ensuring that every drum meets the specified industrial purity standards. We support our partners with comprehensive technical data sheets and safety data sheets (SDS) to facilitate safe handling and regulatory compliance in your facility.
