Intermediates

2-Fluoro-4-nitroaniline

  • CAS No.369-35-7
  • GradeIndustrial / Pharmaceutical
  • Availability● In Stock

High-purity 2-Fluoro-4-nitroaniline (CAS 369-35-7) designed for pharmaceutical synthesis. Reliable supply with comprehensive COA.

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Product Technical Details

Product Overview

2-Fluoro-4-nitroaniline represents a critical class of fluorinated aromatic amines utilized extensively in modern organic synthesis. As a key building block, this compound facilitates the introduction of both fluoro and nitro functional groups into complex molecular architectures. The strategic placement of the fluorine atom at the ortho position relative to the amine group enhances the reactivity profile, making it an invaluable asset for nucleophilic substitution reactions. Our facility specializes in the production of this high-value intermediate, ensuring consistent quality for downstream pharmaceutical and agrochemical applications.

The integration of fluorine atoms into organic molecular structures is a cornerstone of contemporary medicinal chemistry. Fluorinated compounds often exhibit improved metabolic stability, bioavailability, and binding affinity compared to their non-fluorinated counterparts. Consequently, 2-Fluoro-4-nitroaniline serves as a pivotal precursor in the development of advanced therapeutic agents. Our commitment to excellence ensures that every batch meets rigorous international standards, supporting research and production teams globally.

Technical Specifications

We maintain strict control over all production parameters to guarantee product integrity. The following table outlines the key physical and chemical properties verified through our quality assurance protocols. Each shipment is accompanied by a detailed Certificate of Analysis to confirm compliance with specified limits.

ParameterSpecification
CAS Number369-35-7
Molecular FormulaC6H5FN2O2
Molecular Weight156.11 g/mol
AppearanceWhite to tan powder
Purity≥98.0%
Melting Point126-130°C
Density1.448 g/cm3
Boiling Point317.2°C at 760 mmHg

Industrial Applications

This fluorinated intermediate finds extensive utility across multiple sectors within the fine chemicals industry. In pharmaceutical manufacturing, it is employed in the synthesis of quinolone antibiotics and other heterocyclic compounds. The nitro group serves as a versatile handle for further reduction to amines or conversion into other functional groups, enabling diverse synthetic pathways. Additionally, the compound is utilized in the production of specialized agrochemicals where fluorine incorporation enhances pesticidal activity and environmental persistence profiles.

Beyond traditional medicine and agriculture, this material supports research in organic electronics and material science. The electron-withdrawing nature of the nitro group combined with the electronegative fluorine atom creates unique electronic properties suitable for specialized polymer synthesis. Our technical team provides comprehensive support to help clients optimize their synthesis routes and maximize yield efficiency during scale-up processes.

Quality Assurance and Safety

Quality control involves high-performance liquid chromatography and nuclear magnetic resonance spectroscopy to verify structural integrity and purity levels. We adhere to Good Manufacturing Practices to minimize impurities and ensure batch-to-batch consistency. Proper storage ensures stability over extended periods. Users should store the material in a tightly closed container within a cool, dry, and well-ventilated area. It is essential to keep the product away from incompatible substances such as strong oxidizing agents to prevent hazardous reactions.

Our global supply chain infrastructure enables timely delivery to laboratories and production facilities worldwide. We offer flexible packaging options, including standard 25kg drums, to accommodate varying production scales. By choosing our facility as your partner, you gain access to reliable inventory, competitive bulk pricing, and expert technical consultation. We are dedicated to supporting your innovation goals with premium chemical solutions that drive progress in pharmaceutical and industrial development.