Intermediates

2-Fluoro-4-nitrobenzoic acid

  • CAS No.403-24-7
  • GradeIndustrial / Pharmaceutical
  • Availability● In Stock

High-purity 2-Fluoro-4-nitrobenzoic acid (CAS 403-24-7) designed for advanced organic synthesis and pharmaceutical intermediate production.

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Product Technical Details

Product Overview

2-Fluoro-4-nitrobenzoic acid is a highly specialized fluorinated aromatic compound that serves as a critical building block in modern organic synthesis. As a key intermediate, this chemical facilitates the introduction of both fluoro and nitro functional groups into complex molecular structures, making it indispensable for the development of advanced pharmaceutical agents and agrochemical products. Our manufacturing process ensures consistent quality and high purity levels to meet the rigorous demands of research and industrial applications.

The presence of the fluorine atom at the ortho position significantly enhances the metabolic stability and bioavailability of downstream compounds, which is a paramount consideration in medicinal chemistry. This product is synthesized under strictly controlled conditions to minimize impurities and ensure reliable performance in subsequent reaction steps. We prioritize safety and environmental compliance throughout the production lifecycle.

Key Specifications

ParameterValue
Chemical Name2-Fluoro-4-nitrobenzoic acid
CAS Number403-24-7
Molecular FormulaC7H4FNO4
Molecular Weight185.11 g/mol
Purity (HPLC)≥99.0%
AppearanceWhite to pale yellow or light brown powder
Melting Point170°C
Boiling Point352.5°C
Density1.568 g/cm³
Flash Point167°C

Industrial Applications

This fluorinated benzoic acid derivative is extensively utilized in the synthesis of quinolone antibiotics and other therapeutic classes where fluorine substitution is required to optimize pharmacokinetic properties. Beyond pharmaceuticals, it serves as a vital precursor in the production of high-performance polymers and liquid crystal materials. The nitro group provides a versatile handle for further chemical transformations, including reduction to amines or conversion into heterocyclic systems.

Researchers and process chemists value this intermediate for its reactivity profile and stability under standard storage conditions. It is compatible with various coupling reactions and nucleophilic substitutions, allowing for flexible synthetic route design. Our supply chain supports both small-scale laboratory research and large-scale commercial manufacturing needs.

Quality Assurance

Every batch of 2-Fluoro-4-nitrobenzoic acid undergoes comprehensive quality control testing using high-performance liquid chromatography (HPLC) and nuclear magnetic resonance (NMR) spectroscopy. We maintain detailed documentation for each lot, including certificates of analysis (COA) that verify identity, purity, and physical properties. Our quality management system adheres to international standards to ensure product consistency and reliability for our global clientele.

Storage and Handling

To maintain optimal stability, this product should be stored in a cool, ventilated area away from direct sunlight and moisture. Containers must be kept tightly sealed when not in use to prevent contamination or degradation. Personnel handling this chemical should wear appropriate personal protective equipment, including gloves and safety goggles, and work in a well-ventilated environment or fume hood. In case of spillage, standard chemical cleanup procedures should be followed immediately.

Packaging and Logistics

We offer flexible packaging solutions to accommodate diverse customer requirements. The standard packaging configuration is 25 kg per drum, ensuring safe transport and easy handling. Custom packaging options are available upon request to suit specific logistical needs. Our logistics team coordinates global shipping to ensure timely delivery while maintaining compliance with international hazardous material transportation regulations.