2-Fluoro-5-hydroxypyridine
- CAS No.55758-32-2
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High-purity 2-Fluoro-5-hydroxypyridine (CAS 55758-32-2), a key fluorinated heterocyclic intermediate for advanced pharmaceutical synthesis.
Request Bulk PricingProduct Technical Details
Product Overview
2-Fluoro-5-hydroxypyridine is a fluorinated heterocyclic organic compound widely employed as a critical building block in the development of complex pharmaceutical active ingredients. With its unique combination of fluorine and hydroxyl substituents on the pyridine ring, this molecule offers enhanced metabolic stability and binding affinity, making it invaluable in modern medicinal chemistry campaigns targeting central nervous system disorders, oncology therapeutics, and anti-infective agents.
Specifications
| Molecular Formula | C5H4FNO |
|---|---|
| Molecular Weight | 113.09 g/mol |
| CAS Number | 55758-32-2 |
| Appearance | White powder |
| Purity | ≥98.0% |
| Melting Point | 148–150°C |
| Boiling Point | 319.8°C at 760 mmHg |
| Density | 1.325 g/cm³ |
| Refractive Index | 1.526 |
| Flash Point | 147.2 ± 22.3°C |
Industrial Applications
As a versatile fluorinated intermediate, 2-Fluoro-5-hydroxypyridine serves as a foundational scaffold in multi-step synthetic routes for novel drug candidates. Its strategic functional groups enable selective derivatization—such as O-alkylation, N-functionalization, or cross-coupling reactions—to construct structurally diverse libraries for high-throughput screening. The compound is particularly valued in the synthesis of kinase inhibitors, GPCR modulators, and other targeted small-molecule therapeutics where fluorine incorporation improves pharmacokinetic profiles.
- Ideal for structure-activity relationship (SAR) studies in lead optimization
- Compatible with standard peptide coupling and Pd-catalyzed reaction conditions
- Supplied in pharma-grade purity to meet stringent regulatory requirements
Stored in tightly sealed containers under cool, dry conditions, this intermediate maintains stability during extended shelf life. Packaged in 25 kg drums for industrial-scale procurement, it supports seamless integration into cGMP-compliant manufacturing workflows worldwide.
