2-Fluoro-5-iodo-4-methylpyridine

Product Overview

2-Fluoro-5-iodo-4-methylpyridine is a highly specialized halogenated heterocyclic compound that serves as a critical building block in modern medicinal chemistry and organic synthesis. Identified by CAS number 1184913-75-4, this fluorinated pyridine derivative combines the unique reactivity of both fluorine and iodine substituents on a methylated pyridine core. Our facility produces this intermediate under strict quality control standards to ensure consistency for downstream pharmaceutical applications.

The presence of the fluorine atom at the 2-position enhances metabolic stability and lipophilicity in final drug molecules, while the iodine moiety at the 5-position provides an excellent handle for palladium-catalyzed cross-coupling reactions. This dual functionality makes it an invaluable asset for chemists developing kinase inhibitors, agrochemical agents, and advanced functional materials.

Technical Specifications

Industrial Applications

This compound is primarily utilized as a key intermediate in the synthesis of complex pharmaceutical active pharmaceutical ingredients (APIs). The iodine substituent allows for versatile transformations including Suzuki-Miyaura, Heck, and Sonogashira couplings, enabling the construction of biaryl structures common in oncology and anti-inflammatory drug candidates. Furthermore, the fluorine atom contributes to improved bioavailability and binding affinity in target proteins.

Beyond pharmaceuticals, 2-Fluoro-5-iodo-4-methylpyridine finds utility in the development of agrochemicals and specialty organic materials. Researchers value this building block for its stability under various reaction conditions and its compatibility with diverse synthetic routes. Our manufacturing process ensures low levels of residual solvents and heavy metals, meeting the rigorous demands of global supply chains.

Quality Assurance and Storage

Every batch of 2-Fluoro-5-iodo-4-methylpyridine undergoes comprehensive analytical testing, including HPLC, NMR, and GC-MS analysis, to verify identity and purity. We provide a Certificate of Analysis (COA) with each shipment to guarantee compliance with specified parameters. The product is packaged in 25 kg drums lined with protective materials to prevent moisture ingress and contamination.

For optimal stability, store this chemical in a tightly closed container within a cool, dry, and well-ventilated area. Avoid exposure to direct sunlight and strong oxidizing agents. Proper handling procedures should be followed in accordance with safety data sheets to ensure workplace safety. Our logistics team supports global shipping with appropriate documentation for hazardous materials transport.