Intermediates

2-Fluoro-5-methylaniline

  • CAS No.452-84-6
  • GradeIndustrial / Pharmaceutical
  • Availability● In Stock

High purity 2-Fluoro-5-methylaniline (CAS 452-84-6) is a vital light yellow liquid intermediate for pharmaceutical and organic synthesis applications.

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Product Technical Details

Product Overview

2-Fluoro-5-methylaniline stands as a pivotal compound within the realm of fluorinated organic chemistry. This aromatic amine derivative is characterized by the strategic placement of a fluorine atom and a methyl group on the benzene ring, offering unique reactivity profiles essential for modern synthetic pathways. As a key building block, it facilitates the construction of complex molecular architectures required in advanced material science and medicinal chemistry. Our manufacturing process ensures consistent quality, delivering a product that meets rigorous international standards for industrial use.

The introduction of fluorine into organic molecules often enhances metabolic stability and bioavailability, making this intermediate highly sought after in the development of novel pharmaceutical agents. Additionally, its chemical structure allows for versatile functionalization, enabling chemists to derive a wide array of downstream products. We prioritize safety and efficiency in our production facilities to maintain the integrity of this sensitive chemical compound.

Technical Specifications

ParameterValue
Product Name2-Fluoro-5-methylaniline
CAS Number452-84-6
Molecular FormulaC7H8FN
Molecular Weight125.14 g/mol
AppearanceLight yellow transparent liquid
Purity≥98%
Water Content≤0.5%
Density1.109 g/mL at 25 °C
Boiling Point80-86 °C at 11 mm Hg
Refractive Indexn20/D 1.533

Industrial Applications

This fluorinated aniline derivative serves as a fundamental precursor in the synthesis of various agrochemicals and pharmaceuticals. Its high reactivity allows for efficient coupling reactions, making it indispensable in the production of active pharmaceutical ingredients (APIs). Researchers utilize this compound to explore new therapeutic avenues, particularly where fluorine substitution is critical for drug performance. Beyond healthcare, it finds application in the creation of specialized polymers and liquid crystals.

Our global clientele relies on this intermediate for scaling up production from laboratory research to commercial manufacturing. The consistency of our batch-to-batch quality ensures that downstream processes remain stable and predictable. Whether used in cross-coupling reactions or nucleophilic substitutions, 2-Fluoro-5-methylaniline provides the reliability needed for high-stakes chemical synthesis.

Quality And Safety

We adhere to strict quality control protocols to guarantee the purity and safety of every drum shipped. Each batch undergoes comprehensive testing using advanced analytical techniques such as Gas Chromatography and Nuclear Magnetic Resonance. A Certificate of Analysis (COA) is provided with every order to verify compliance with specified parameters. Proper handling is essential due to the chemical nature of the product.

Storage requirements include keeping the container tightly closed in a cool, dry, and well-ventilated area. The product should be protected from moisture and direct sunlight to prevent degradation. Transport is conducted according to international hazardous material regulations, ensuring safe delivery to your facility. Our team is available to provide technical support and safety data sheets to assist with your compliance needs.