Intermediates

2-Fluoro-5-methylbenzonitrile

  • CAS No.64113-84-4
  • GradeIndustrial / Pharmaceutical
  • Availability● In Stock

High purity 2-Fluoro-5-methylbenzonitrile (CAS 64113-84-4) designed for pharmaceutical intermediate synthesis. Available in bulk quantities with comprehensive quality documentation.

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Product Technical Details

Product Overview

2-Fluoro-5-methylbenzonitrile is a specialized fluorinated organic compound serving as a critical building block in modern medicinal chemistry. This aromatic nitrile derivative is characterized by the presence of both fluoro and methyl substituents on the benzene ring, providing unique reactivity profiles essential for complex molecular construction. Our facility produces this chemical intermediate under strict quality control standards to ensure consistency for downstream pharmaceutical applications.

As a key precursor, this compound facilitates the development of advanced therapeutic agents. The strategic placement of the fluorine atom enhances metabolic stability and bioavailability in final drug candidates, making it a preferred choice for research and development teams focused on novel drug discovery.

Technical Specifications

We adhere to rigorous manufacturing protocols to deliver material that meets or exceeds industry standards. The following table outlines the critical physical and chemical parameters verified during our quality assurance process.

Parameter Specification
CAS Number 64113-84-4
Molecular Formula C8H6FN
Molecular Weight 135.14 g/mol
Purity (GC) ≥99.0%
Appearance White to off-white powder
Melting Point 50-52°C
Boiling Point 204°C
Density 1.11 g/cm³
Refractive Index 1.507

Industrial Applications

This fluorinated benzonitrile derivative is primarily utilized in the synthesis of heterocyclic compounds, including indazoles. These structures are significant in the field of pharmacological research, particularly for targeting specific adrenoceptors. The compound supports the creation of molecules with potential selectivity for the α2-adrenoceptor, which is relevant for studies involving central and peripheral nervous system functions.

Beyond specific receptor targeting, the chemical versatility of this nitrile allows for various transformation reactions, such as hydrolysis to carboxylic acids or reduction to amines. This flexibility makes it an invaluable asset for synthetic chemists designing multi-step synthesis routes for active pharmaceutical ingredients (APIs). Our global clientele relies on this material for scaling up processes from laboratory benchtop to pilot plant operations.

Storage and Handling

To maintain optimal stability and safety, proper storage conditions are essential. The product should be kept in a cool, well-ventilated area away from direct sunlight and moisture. Containers must remain tightly sealed when not in use to prevent contamination or degradation. Standard laboratory safety practices should be followed during handling, including the use of appropriate personal protective equipment such as gloves and safety goggles.

We recommend storing the material in its original packaging until ready for use. In case of spills, standard chemical containment procedures should be implemented immediately. Our technical team provides comprehensive safety data sheets and handling guides to ensure compliance with local regulations and workplace safety standards.

Quality Assurance and Supply

As a leading global manufacturer, we prioritize supply chain reliability and product integrity. Each batch undergoes thorough analytical testing, and a Certificate of Analysis (COA) is provided with every shipment. We offer flexible packaging options, including standard 25 kg drums, and can accommodate custom requirements based on project needs. Our commitment to quality ensures that your research and production timelines are met without compromise.