Intermediates

2-Fluoro-5-methylpyridine

  • CAS No.2369-19-9
  • GradeIndustrial / Pharmaceutical
  • Availability● In Stock

High-purity 2-Fluoro-5-methylpyridine is an essential fluorinated heterocyclic intermediate for pharmaceutical synthesis. Available in bulk with strict quality control and global shipping.

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Product Technical Details

Product Overview

2-Fluoro-5-methylpyridine represents a critical fluorinated heterocyclic compound widely utilized in modern organic synthesis and medicinal chemistry. As a key building block, this substance plays an indispensable role in the development of advanced pharmaceutical intermediates and fine chemicals. Our facility produces this chemical under strict quality control standards to ensure consistent performance in downstream reactions. The presence of the fluorine atom at the second position significantly enhances the metabolic stability and bioavailability of final drug candidates, making this reagent highly valued in research and industrial production.

Manufactured using state-of-the-art fluorination technologies, our product delivers exceptional purity levels suitable for sensitive synthetic pathways. We understand the rigorous demands of the pharmaceutical industry and commit to providing materials that meet international specifications. Whether used for nucleophilic substitution or cross-coupling reactions, this pyridine derivative offers reliable reactivity and stability. Our team ensures that every batch is tested thoroughly to maintain the highest standards of quality and safety for our global partners.

Technical Specifications

Parameter Value
CAS Number 2369-19-9
Molecular Formula C6H6FN
Molecular Weight 111.12 g/mol
Appearance Colorless liquid
Purity ≥99.0%
Boiling Point 158-159 °C
Density 1.072 g/mL
Refractive Index 1.473
Flash Point 119 °F

Industrial Applications

This fluorinated pyridine derivative serves as a versatile intermediate in the synthesis of various agrochemicals and pharmaceuticals. Its primary application lies in the construction of complex molecular architectures where specific substitution patterns are required. Chemists utilize this compound to introduce fluorine motifs into drug molecules, which is a common strategy to improve pharmacokinetic properties. Additionally, it acts as a precursor for producing specialized ligands and catalysts used in homogeneous catalysis.

Due to its high reactivity, it is frequently employed in palladium-catalyzed coupling reactions such as Suzuki or Buchwald processes. The methyl group at the fifth position provides additional functionality for further derivatization, allowing for diverse chemical transformations. Our clients in the fine chemical sector rely on this material for developing new active pharmaceutical ingredients. The consistent quality ensures reproducible results in large-scale manufacturing processes, reducing waste and improving overall yield efficiency.

Quality Assurance and Storage

  • Strict quality control testing for every batch using GC and HPLC.
  • Certificate of Analysis (COA) provided with every shipment.
  • Packaged in secure drums to prevent contamination and leakage.
  • Stored in a cool, dry environment away from moisture and heat.

Proper storage is essential to maintain the integrity of this chemical. We recommend keeping the container tightly closed in a well-ventilated area. Our logistics team ensures safe global delivery compliant with hazardous material regulations. For technical support or bulk pricing inquiries, our sales team is ready to assist with your specific project requirements. We prioritize customer satisfaction and long-term partnerships through reliable supply chains.