2-Fluoro-5-nitropyridine

Product Overview

2-Fluoro-5-nitropyridine represents a critical class of fluorinated heterocyclic compounds essential for modern medicinal chemistry and agrochemical development. As a specialized pharmaceutical intermediate, this compound serves as a versatile building block for constructing complex molecular architectures. The strategic placement of the fluorine atom at the second position of the pyridine ring, combined with the nitro group at the fifth position, creates a highly reactive system ideal for nucleophilic aromatic substitution reactions.

Our manufacturing facility produces this chemical under stringent quality assurance protocols to ensure consistency across batches. We understand that in the synthesis of active pharmaceutical ingredients (APIs), even minor impurities can affect downstream reactions. Therefore, we maintain a purity level of ≥99.0%, providing researchers and industrial chemists with a reliable foundation for their synthesis routes.

Key Specifications

Physical and Chemical Properties

The physical characteristics of 2-Fluoro-5-nitropyridine are well-defined to assist in process optimization. The compound exhibits a density of approximately 1.439 g/cm³, indicating a compact molecular structure typical of halogenated heterocycles. It has a melting point range of 142-144°C, which serves as a key identifier for quality control during incoming inspection. The boiling point is recorded at 237.5°C at 760 mmHg, suggesting stability under standard atmospheric pressure during distillation or purification processes.

With a flash point of 103.8°C, the material requires standard chemical handling precautions regarding heat sources. The index of refraction is measured at 1.538, further confirming the optical properties consistent with high-grade fluorinated pyridines. These properties make it suitable for various reaction conditions commonly found in industrial organic synthesis.

Industrial Applications

This fluorinated pyridine derivative is predominantly utilized as a precursor in the synthesis of pharmaceutical intermediates. The fluorine atom acts as a leaving group or a metabolic stabilizer in final drug molecules, enhancing bioavailability and binding affinity. Chemists frequently employ this compound in the development of kinase inhibitors, antiviral agents, and other therapeutic classes where pyridine scaffolds are prevalent.

• Used in nucleophilic substitution reactions to introduce functional groups.
• Serves as a key intermediate in the production of novel agrochemicals.
• Employed in research and development for new drug discovery programs.
• Utilized in the synthesis of liquid crystals and advanced materials.

Packaging, Storage, and Safety

To maintain product integrity, 2-Fluoro-5-nitropyridine is packaged in secure 25 kg drums lined with moisture-resistant materials. Proper storage is essential; the product should be kept in a tightly closed container within a cool, dry, and well-ventilated area. Avoid exposure to direct sunlight and incompatible materials such as strong oxidizing agents. We provide comprehensive documentation, including Certificates of Analysis (COA) and Safety Data Sheets (SDS), with every shipment to ensure compliance with global regulatory standards.