2-Fluoro-6-iodobenzoic acid
- CAS No.111771-08-5
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
Premium grade 2-Fluoro-6-iodobenzoic acid (CAS 111771-08-5) designed for complex organic synthesis. High purity ≥98.0% ensures reliable reaction yields for pharmaceutical and agrochemical development.
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Product Overview
2-Fluoro-6-iodobenzoic acid is a highly specialized fluorinated aromatic intermediate that plays a critical role in modern medicinal chemistry and advanced organic synthesis. Characterized by the presence of both fluorine and iodine substituents on the benzoic acid backbone, this compound offers unique reactivity profiles that are essential for constructing complex molecular architectures. The strategic placement of the halogen atoms allows chemists to leverage orthogonal reactivity, enabling selective transformations that are vital in the development of new pharmaceutical agents and agrochemical products.
As a key building block, this substance is particularly valued for its utility in cross-coupling reactions, such as Suzuki-Miyaura or Sonogashira couplings, where the iodine moiety serves as an excellent leaving group. Simultaneously, the fluorine atom contributes to the metabolic stability and bioavailability of the final drug candidates, making this intermediate a preferred choice for process research and development teams aiming to optimize lead compounds.
Technical Specifications
Our manufacturing process adheres to strict quality control standards to ensure consistency and reliability across every batch. The following table outlines the key physical and chemical properties verified through our analytical laboratories.
| Parameter | Specification |
|---|---|
| CAS Number | 111771-08-5 |
| Molecular Formula | C7H4FIO2 |
| Molecular Weight | 266.008 g/mol |
| Appearance | White to off-white powder |
| Assay (Purity) | ≥98.0% |
| Melting Point | 123-126 °C |
| Density | 2.1±0.1 g/cm3 |
| Boiling Point | 301.6±27.0 °C at 760 mmHg |
| Flash Point | 136.2±23.7 °C |
Industrial Applications
This fluorinated benzoic acid derivative is extensively utilized in the synthesis of kinase inhibitors, anti-inflammatory agents, and other therapeutic classes where halogenated aromatic rings are required. Beyond pharmaceuticals, it serves as a versatile precursor in the production of high-performance polymers and liquid crystal materials. The high purity grade provided ensures minimal impurity carryover into downstream processes, reducing purification burdens and improving overall process efficiency.
- Pharmaceutical Intermediate: Essential for creating bioactive molecules with enhanced metabolic profiles.
- Agrochemical Synthesis: Used in the development of novel herbicides and pesticides.
- Material Science: Applied in the formulation of advanced organic materials and electronic chemicals.
- Research and Development: Ideal for laboratory-scale optimization and scale-up studies.
Quality Assurance and Handling
We maintain a robust quality management system to guarantee that every drum meets the specified assay and physical parameters. Each shipment is accompanied by a comprehensive Certificate of Analysis (COA) detailing batch-specific test results. For optimal stability, the product should be stored in a cool, ventilated area away from direct sunlight and moisture. Standard packaging includes 25 kg drums, though custom packaging solutions are available to meet specific logistical requirements. Our global supply chain ensures timely delivery while maintaining the integrity of the chemical throughout transit.
