2-Fluoroacetophenone
- CAS No.445-27-2
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High-purity 2-Fluoroacetophenone (CAS 445-27-2) designed for pharmaceutical and organic synthesis applications. Reliable supply with strict quality control.
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Product Overview
2-Fluoroacetophenone, also known by its systematic name 1-(2-fluorophenyl)ethanone, is a vital fluorinated aromatic ketone widely utilized in the fine chemical and pharmaceutical industries. As a key building block, this compound plays a critical role in the construction of complex molecular architectures. The introduction of a fluorine atom at the ortho position significantly alters the electronic and steric properties of the molecule, making it an indispensable reagent for modern medicinal chemistry and agrochemical development.
Our manufacturing facility adheres to rigorous quality management systems to ensure that every batch of 2-Fluoroacetophenone meets or exceeds international standards. We understand that consistency in raw materials is paramount for downstream synthesis success. Therefore, we employ advanced distillation and purification techniques to achieve high purity levels, minimizing impurities that could interfere with sensitive catalytic reactions or subsequent synthetic steps.
Key Specifications and Quality Control
Quality assurance is the cornerstone of our production process. Each shipment is accompanied by a comprehensive Certificate of Analysis (COA) detailing specific test results against our factory standards. The following table outlines the typical physical and chemical properties along with our quality specifications:
| Parameter | Specification | Typical Result |
|---|---|---|
| Appearance | Colorless clear liquid | Conform |
| CAS Number | 445-27-2 | Verified |
| Purity (Assay) | ≥99.0% | 99.64% |
| Moisture Content | ≤0.2% | 0.02% |
| Total Impurities | ≤1.0% | 0.36% |
| Density | 1.137 g/mL at 20°C | Conform |
| Boiling Point | 187-189°C | Conform |
In addition to standard parameters, we actively monitor specific isomers such as 3'-Fluoroacetophenone to ensure regiochemical purity. Our analytical laboratory utilizes gas chromatography and other sophisticated methods to verify that single impurities remain well below the 0.5% threshold, guaranteeing reliability for high-stakes synthesis projects.
Industrial Applications
This fluorinated ketone serves as a versatile intermediate in various chemical sectors. Its primary applications include:
- Pharmaceutical Synthesis: Used as a precursor for developing novel therapeutic agents where fluorine substitution enhances metabolic stability and bioavailability.
- Organic Chemistry: Acts as an electrophilic building block for forming carbon-carbon bonds in complex organic synthesis routes.
- Agrochemical Development: Employed in the creation of advanced pesticides and herbicides requiring specific aromatic substitution patterns.
- Material Science: Utilized in the research and development of specialized polymers and functional materials.
Storage and Handling
To maintain product integrity, 2-Fluoroacetophenone should be stored in a cool, dry, and well-ventilated area away from incompatible substances such as strong oxidizers and corrosives. Containers must remain tightly closed when not in use to prevent moisture absorption and contamination. We recommend keeping the material away from heat, sparks, and open flames due to its combustible nature. Our packaging options include 25 kg drums, with custom packaging solutions available to meet specific logistical requirements for global shipping.
