2-Fluorophenylboronic acid
- CAS No.1993-03-9
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High purity 2-Fluorophenylboronic acid for organic synthesis. Reliable supply for pharmaceutical intermediate production with strict quality control.
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Product Overview
2-Fluorophenylboronic acid is a critical organoboron compound widely utilized in modern organic synthesis and medicinal chemistry. As a key building block, this chemical facilitates efficient carbon-carbon bond formation through palladium-catalyzed cross-coupling reactions. Our manufacturing process ensures high consistency and purity, making it an ideal choice for complex molecule construction in research and industrial scales.
This compound features a fluorine substituent at the ortho position of the phenyl ring, which significantly influences its reactivity and stability during synthetic transformations. The presence of the boronic acid group allows for versatile functionalization, enabling chemists to introduce fluorinated motifs into diverse molecular scaffolds. We prioritize quality assurance to meet the rigorous demands of pharmaceutical and fine chemical sectors.
Technical Specifications
| Parameter | Specification |
|---|---|
| Product Name | 2-Fluorophenylboronic acid |
| CAS Number | 1993-03-9 |
| Molecular Formula | C6H6BFO2 |
| Molecular Weight | 139.92 g/mol |
| Appearance | White to light yellow crystalline powder |
| Assay | ≥98.0% |
| Water Content | ≤0.50% |
| Melting Point | 101-110 °C |
| Density | 1.3±0.1 g/cm3 |
| Boiling Point | 267.8±42.0 °C at 760 mmHg |
Industrial Applications
The primary application of 2-Fluorophenylboronic acid lies in its role as a versatile intermediate for pharmaceutical synthesis. It is extensively employed in Suzuki-Miyaura coupling reactions to construct biaryl structures found in numerous active pharmaceutical ingredients. The fluorine atom enhances metabolic stability and bioavailability of the final drug candidates, making this reagent invaluable in drug discovery pipelines.
Beyond pharmaceuticals, this chemical serves as a crucial component in the development of advanced materials and agrochemicals. Its high reactivity allows for precise modifications in organic frameworks. Key advantages for industrial users include:
- High purity levels ensuring minimal side reactions during synthesis.
- Excellent stability under standard storage conditions.
- Compatible with various catalytic systems for flexible process design.
- Cost-effective solution for large-scale manufacturing requirements.
Quality Assurance and Storage
We maintain strict quality control protocols throughout production. Each batch undergoes comprehensive testing including HPLC analysis to verify assay purity and water content. A Certificate of Analysis (COA) is provided with every shipment to guarantee compliance with specified standards. Our facility adheres to international safety and environmental regulations.
For optimal preservation, store the product in a cool, dry, and well-ventilated area. Keep containers tightly closed to prevent moisture absorption, which may affect stability. The substance is classified as non-dangerous goods for transport, facilitating straightforward logistics. Packaging is available in 25kg drums or customized according to specific client requirements to ensure safe delivery globally.
