2-Hydroxy-3-methoxy-3,3-diphenylpropanoic acid
- CAS No.178306-52-0
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High-purity 2-Hydroxy-3-methoxy-3,3-diphenylpropanoic acid (CAS 178306-52-0) for Ambrisentan synthesis. Reliable supply with COA.
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Product Overview
2-Hydroxy-3-methoxy-3,3-diphenylpropanoic acid is a specialized organic compound serving as a critical building block in the pharmaceutical industry. Identified by CAS number 178306-52-0, this chemical intermediate plays a pivotal role in the synthesis of advanced therapeutic agents, particularly within the cardiovascular sector. Our manufacturing process ensures consistent quality and high purity levels, meeting the rigorous demands of modern drug development pipelines.
As a key precursor, this compound features a unique structural configuration that facilitates specific stereoselective reactions. The presence of hydroxy and methoxy functional groups alongside diphenyl substituents provides the necessary chemical reactivity for downstream transformations. We specialize in producing this intermediate at scale, supporting both research and commercial production needs for global pharmaceutical partners.
Specifications and Physical Properties
Quality control is paramount in the production of pharmaceutical intermediates. Our facility adheres to strict testing protocols to verify identity, purity, and physical characteristics. The following table outlines the standard specifications for this product batch:
| Parameter | Value |
|---|---|
| CAS Number | 178306-52-0 |
| Molecular Formula | C16H16O4 |
| Molecular Weight | 272.30 g/mol |
| Appearance | Beige to greyish-beige powder |
| Purity | ≥98% |
| Moisture Content | ≤1% |
| Density | 1.248 g/cm3 |
| Boiling Point | 430.3±45.0 °C at 760 mmHg |
Industrial Applications
The primary application of 2-Hydroxy-3-methoxy-3,3-diphenylpropanoic acid is in the synthesis of Ambrisentan, an endothelin receptor antagonist used to treat pulmonary arterial hypertension. Its structural integrity is essential for ensuring the efficacy and safety of the final active pharmaceutical ingredient. Beyond this specific use, the compound serves as a valuable template for developing analogous structures in medicinal chemistry research.
Our supply chain is optimized to deliver this intermediate reliably to R&D laboratories and manufacturing plants worldwide. We understand the critical nature of supply continuity in drug production and maintain robust inventory levels to prevent disruptions. Technical support is available to assist with integration into your specific synthesis routes.
Quality Assurance and Storage
Each batch undergoes comprehensive analysis using HPLC, NMR, and mass spectrometry to confirm compliance with specifications. A Certificate of Analysis (COA) is provided with every shipment to document quality metrics. Proper storage is essential to maintain stability over time.
- Store in a cool and dry well-closed container.
- Keep away from moisture and strong light or heat sources.
- Packaging available in 25kg cardboard drums or per customer requirements.
- Shelf life extends significantly when stored under recommended conditions.
We are committed to providing high-quality chemical intermediates that empower innovation in pharmaceutical manufacturing. Contact our team for bulk pricing, custom synthesis options, and detailed technical documentation.
