2-Hydroxy-5-trifluoromethylpyridine
- CAS No.33252-63-0
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High-purity 2-Hydroxy-5-trifluoromethylpyridine (CAS 33252-63-0) designed for advanced organic synthesis. Reliable supply for pharmaceutical and agrochemical intermediate manufacturing.
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Product Overview
2-Hydroxy-5-trifluoromethylpyridine is a specialized fluorinated heterocyclic compound that serves as a critical building block in modern organic synthesis. Characterized by the presence of a trifluoromethyl group at the fifth position of the pyridine ring, this molecule offers unique electronic and steric properties that enhance the biological activity and metabolic stability of downstream pharmaceutical candidates. Our facility produces this intermediate under strict quality control protocols to ensure consistency for research and industrial applications.
As a key precursor in medicinal chemistry, this compound is frequently utilized in the development of novel therapeutic agents, particularly those targeting central nervous system disorders and oncological pathways. The incorporation of fluorine atoms often improves lipophilicity and bioavailability, making this pyridine derivative highly valued by process chemists and formulation scientists alike.
Technical Specifications
| Parameter | Specification |
|---|---|
| CAS Number | 33252-63-0 |
| Molecular Formula | C6H4F3NO |
| Molecular Weight | 163.097 g/mol |
| Appearance | Off-white crystalline powder |
| Assay (Purity) | ≥98.0% |
| Melting Point | 145-149 °C |
| Boiling Point | 286.8±35.0 °C at 760 mmHg |
| Density | 1.4±0.1 g/cm3 |
| Flash Point | 127.3±25.9 °C |
| Refractive Index | 1.457 |
Industrial Applications
This fluorinated pyridine intermediate is primarily employed in the synthesis of complex pharmaceutical APIs and agrochemical active ingredients. Its robust chemical structure allows for various functionalization reactions, including nucleophilic substitution and cross-coupling processes. Manufacturers utilize this material to introduce specific pharmacophores into larger molecular frameworks, enabling the creation of drugs with enhanced potency and selectivity.
Beyond pharmaceuticals, the compound finds utility in the production of advanced materials and specialty chemicals where thermal stability and chemical resistance are required. The trifluoromethyl moiety contributes to the overall durability of the final product, making it suitable for demanding environmental conditions.
Quality Assurance and Packaging
We adhere to international quality management standards to guarantee the integrity of every batch. Each shipment is accompanied by a comprehensive Certificate of Analysis (COA) detailing physical and chemical test results. Our production process minimizes impurities, ensuring that the material meets the rigorous demands of multi-step synthesis routes.
Standard packaging consists of 25 kg drums, designed to protect the product from moisture and light during transit. Custom packaging solutions are available upon request to accommodate specific logistical requirements. We recommend storing the material in a cool, ventilated area away from incompatible substances to maintain optimal stability over time.
